酒精与烟草共同暴露对下咽癌风险的影响。
Effect of combined alcohol and tobacco exposure on risk of cancer of the hypopharynx.
作者信息
Olsen J, Sabroe S, Ipsen J
出版信息
J Epidemiol Community Health. 1985 Dec;39(4):304-7. doi: 10.1136/jech.39.4.304.
The effect of moderate to heavy exposure to alcohol and tobacco on the risk of cancer of the hypopharynx is estimated in a case-control study. All incident hypopharyngeal cancer patients in Denmark who were under 75 years of age were compared with incident cases of laryngeal cancer and population sampled controls. The ascertainment of cases and controls took place during March 1980 to March 1982. Thirty-two patients with cancer of the hypopharynx, 321 patients with cancer of the larynx, and 1141 population sampled controls participated in the study. The effect of combined exposure to alcohol and tobacco seemed to be multiplicative rather than additive, a finding which is similar to that in laryngeal cancer patients. However, as there were only small numbers, only major deviations from the additive or multiplicative model for interaction would be detectable.
在一项病例对照研究中，评估了中度至重度饮酒和吸烟对下咽癌风险的影响。丹麦所有75岁以下的下咽癌新发病例患者与喉癌新发病例及人群抽样对照进行了比较。病例和对照的确定在1980年3月至1982年3月期间进行。32名下咽癌患者、321名喉癌患者和1141名人群抽样对照参与了该研究。酒精和烟草联合暴露的影响似乎是相乘而非相加的，这一发现与喉癌患者的情况相似。然而，由于数量较少，只有与相加或相乘相互作用模型的重大偏差才能被检测到。
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