Hyypiä T, Eskola J, Laine M, Meurman O
Infect Immun. 1984 Feb;43(2):589-92. doi: 10.1128/iai.43.2.589-592.1984.
B-cell function in vitro was studied in patients with natural rubella virus infection. Lymphocyte responses to mitogens in a blast transformation test were decreased at the onset of the rash. Spontaneous immunoglobulin production by peripheral blood lymphocytes was increased during the acute phase of illness. In regulatory T-cell subpopulations, increased proportions of cells with suppressor/cytotoxic phenotypes and decreased proportions of cells with helper/inducer phenotypes were detected simultaneously with the increased spontaneous immunoglobulin production. All parameters studied were recovered during the convalescent phase.
对自然感染风疹病毒的患者进行了体外B细胞功能研究。在出疹开始时，淋巴细胞在促有丝分裂原刺激试验中的反应降低。在疾病急性期，外周血淋巴细胞自发免疫球蛋白产生增加。在调节性T细胞亚群中，在自发免疫球蛋白产生增加的同时，检测到具有抑制/细胞毒性表型的细胞比例增加，而具有辅助/诱导表型的细胞比例降低。所有研究参数在恢复期均恢复正常。
