van Dixhoorn J, Duivenvoorden H J
J Psychosom Res. 1985;29(2):199-206. doi: 10.1016/0022-3999(85)90042-x.
The pattern of complaints of patients with the hyperventilation syndrome (HVS) was studied on the basis of the Nijmegen HVS Questionnaire (van Doorn, Colla, Folgering). This list was completed by 75 patients with the clinical diagnosis HVS. Non-metric principal components analysis (NMPCA) showed that the structure was three-dimensional, the dimensions being labelled: Shortness of breath (HVS-1), Peripheral tetany (HVS-II), Central tetany (HVS-III). The questionnaire's differentiating ability was investigated by comparing HVS patients with non-HVS persons (80 persons employed in health care). All three components had an unequivocally high ability to differentiate between HVS and non-HVS. Application of linear analysis of discriminance to HVS-I, HVS-II and HVS-III together yielded 93% correct classifications. Statistical double cross-validation resulted in 90 and 94% correct classifications. The sensitivity of the Nijmegen Questionnaire in relation to the clinical diagnosis was 91% and the specificity 95%. It is concluded that the questionnaire is suitable as a screening instrument for early detection of HVS, and also as an aid in diagnosis and therapy planning.
基于奈梅亨过度换气综合征问卷（范·杜恩、科拉、福尔杰林）对过度换气综合征（HVS）患者的主诉模式进行了研究。这份问卷由75名临床诊断为HVS的患者填写。非度量主成分分析（NMPCA）表明该结构是三维的，这些维度分别标记为：呼吸急促（HVS - I）、外周手足搐搦（HVS - II）、中枢手足搐搦（HVS - III）。通过将HVS患者与非HVS人群（80名医疗保健行业从业者）进行比较，对该问卷的区分能力进行了研究。所有三个成分都具有明确的高区分HVS与非HVS的能力。对HVS - I、HVS - II和HVS - III一起进行判别线性分析，正确分类率为93%。统计双重交叉验证得到的正确分类率为90%和94%。奈梅亨问卷相对于临床诊断的敏感性为91%，特异性为95%。得出的结论是，该问卷适合作为早期检测HVS的筛查工具，也有助于诊断和治疗规划。
