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Chlorhexidine Gluconate Baths: Supporting Daily Use to Reduce Central Line-Associated Bloodstream Infections Affecting Immunocompromised Patients.葡萄糖酸洗必泰沐浴：支持日常使用以减少影响免疫功能低下患者的中心静脉导管相关血流感染
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Chlorhexidine gluconate or polyhexamethylene biguanide disc dressing to reduce the incidence of central-line-associated bloodstream infection: a feasibility randomized controlled trial (the CLABSI trial).葡萄糖酸氯己定或聚六亚甲基双胍圆盘敷料减少中心静脉相关血流感染的发生率：一项可行性随机对照试验（CLABSI 试验）。
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本文引用的文献

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Incidence of Catheter-Associated Bloodstream Infections in Stem Cell Recipients-Should We Be "PICCy"?干细胞接受者中导管相关血流感染的发生率——我们应该“挑剔”吗？
Cancers (Basel). 2024 Mar 21;16(6):1239. doi: 10.3390/cancers16061239.
2
Bathing with wipes impregnated with chlorhexidine gluconate to prevent central line-associated bloodstream infection in critically ill patients: A systematic review with meta-analysis.用氯己定葡萄糖酸盐浸渍的湿巾擦拭洗澡以预防危重症患者的中心静脉相关血流感染：系统评价与荟萃分析。
Am J Infect Control. 2024 Jun;52(6):731-738. doi: 10.1016/j.ajic.2024.01.019. Epub 2024 Feb 10.
3
Reduction in patient refusal of CHG bathing.降低患者对氯己定洗澡的拒绝率。
Am J Infect Control. 2023 Sep;51(9):1034-1037. doi: 10.1016/j.ajic.2023.01.007. Epub 2023 Feb 2.
4
A Quality Improvement Project to Decrease CLABSIs in Non-ICU Settings.非 ICU 环境下降低 CLABSI 的质量改进项目。
Qual Manag Health Care. 2023;32(3):189-196. doi: 10.1097/QMH.0000000000000375. Epub 2022 Nov 5.
5
Prevalence of Central Line-Associated Bloodstream Infections (CLABSI) in Intensive Care and Medical-Surgical Units.重症监护病房及内科-外科病房中心静脉导管相关血流感染（CLABSI）的发生率
Cureus. 2022 Mar 3;14(3):e22809. doi: 10.7759/cureus.22809. eCollection 2022 Mar.
6
Association of CLABSI With Hospital Length of Stay, Readmission Rates, and Mortality: A Retrospective Review.中心静脉导管相关血流感染与住院时间、再入院率及死亡率的关联：一项回顾性研究。
Worldviews Evid Based Nurs. 2021 Dec;18(6):332-338. doi: 10.1111/wvn.12548. Epub 2021 Nov 14.
7
Results of the CHlorhexidine Gluconate Bathing implementation intervention to improve evidence-based nursing practices for prevention of central line associated bloodstream infections Study (CHanGing BathS): a stepped wedge cluster randomized trial.葡萄糖酸氯己定沐浴实施干预以改善基于证据的预防中心静脉相关血流感染护理实践的研究（CHanGing BathS）结果：一项阶梯式楔形集群随机试验。
Implement Sci. 2021 Apr 26;16(1):45. doi: 10.1186/s13012-021-01112-4.
8
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.PRISMA 2020 声明：系统评价报告的更新指南。
BMJ. 2021 Mar 29;372:n71. doi: 10.1136/bmj.n71.
9
Chlorhexidine Gluconate Bathing Reduces the Incidence of Bloodstream Infections in Adults Undergoing Inpatient Hematopoietic Cell Transplantation.葡萄糖酸氯己定沐浴可降低接受住院造血细胞移植的成人血流感染的发生率。
Transplant Cell Ther. 2021 Mar;27(3):262.e1-262.e11. doi: 10.1016/j.jtct.2021.01.004. Epub 2021 Jan 7.
10
Is it cost effective to use a 2% chlorhexidine wipes bath to reduce central-line associated blood stream infection? A quasi-experimental study.使用 2%洗必泰湿巾擦浴以降低中心静脉相关血流感染的成本效益如何？一项准实验研究。
Braz J Infect Dis. 2021 Jan-Feb;25(1):101538. doi: 10.1016/j.bjid.2021.101538. Epub 2021 Jan 27.

葡萄糖酸氯己定治疗中护士与患者的依从性对减少中心静脉导管相关血流感染的作用

Chlorhexidine Gluconate Treatment Adherence Among Nurses and Patients to Reduce Central Line-Associated Bloodstream Infections.

作者信息

Kuroki Mika, Short Abigail C, Coombs Lorinda A

机构信息

Mika Kuroki.

Abigail C. Short.

出版信息

Clin J Oncol Nurs. 2025 Mar 14;29(2):E37-E46. doi: 10.1188/25.CJON.E37-E46.

DOI:10.1188/25.CJON.E37-E46
PMID:40096554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12056876/
Abstract

BACKGROUND

Chlorhexidine gluconate (CHG), an antimicrobial topical treatment, reduces central line-associated bloodstream infections (CLABSIs). However, many barriers exist to CHG use, limiting the benefits of this evidence-based intervention.

OBJECTIVES

This review aimed to identify effective CHG interventions to reduce CLABSIs in patients with cancer, particularly those undergoing bone marrow transplantations.

METHODS

PubMed® and CINAHL® databases were searched for articles published in English between 2014 and 2024 that focused on adults (aged 18 years or older) and evaluated CHG use, barriers to CHG use, and interventions to reduce CLABSI rates.

FINDINGS

This review identified the following three themes: the efficacy of CHG on reducing hospital-acquired infections, barriers to CHG use, and multilevel educational programs that improve rates of CHG use.

摘要

背景

葡萄糖酸氯己定（CHG）作为一种局部抗菌治疗药物，可降低中心静脉导管相关血流感染（CLABSI）的发生率。然而，CHG的使用存在诸多障碍，限制了这种循证干预措施的益处。

目的

本综述旨在确定有效的CHG干预措施，以降低癌症患者，尤其是接受骨髓移植患者的CLABSI发生率。

方法

检索PubMed®和CINAHL®数据库，查找2014年至2024年期间以英文发表的、聚焦于成年人（18岁及以上）且评估了CHG使用情况、CHG使用障碍以及降低CLABSI发生率干预措施的文章。

结果

本综述确定了以下三个主题：CHG在降低医院获得性感染方面的疗效、CHG使用障碍以及提高CHG使用率的多层次教育项目。