St Laurent Christine W, Lokhandwala Sanna, Allard Tamara, Ji Angela, Paluch Amanda, Riggins Tracy, Spencer Rebecca M C
Department of Kinesiology, University of Massachusetts Amherst, 30 Eastman Lane, Amherst, MA, 01003, USA.
Department of Psychological and Brain Sciences, University of Massachusetts Amherst, Amherst, USA.
Sci Rep. 2025 Mar 17;15(1):9205. doi: 10.1038/s41598-025-92932-7.
This study aimed to determine if 24-h movement behaviors (sedentary time, physical activity, and sleep), considered independently and together, were associated with declarative memory and hippocampal volume in late early childhood. Observational data were obtained from preschool-aged children (timepoint 1: n = 35 children, 3.9 ± 0.5 years; 6 months later: n = 28 children, 4.5 ± 0.5 years). Movement behaviors were measured with actigraphy. Outcomes were declarative memory and hippocampal subregion volumes. Multilevel models explored movement behaviors independently as absolute values, and with both absolute total activity, 24-h sleep duration, and night sleep efficiency. Movement behaviors were also explored as compositions in linear regression models. In independent models, sleep duration and moderate to vigorous physical activity were positively associated with total and right hippocampal volumes, respectively. When examined together, children meeting sleep recommendations were more likely to have larger total, right and left hemisphere, body, and tail hippocampal volumes. In our sample of preschool children, we observed positive associations between sleep duration and hippocampal volume, independent of age. To improve our understanding of the connections between 24-h behaviors and brain health in early childhood, larger samples that also consider the context and subcomponents of movement behaviors may be warranted.
本研究旨在确定24小时运动行为（久坐时间、身体活动和睡眠）单独及综合考虑时，是否与幼儿晚期的陈述性记忆和海马体体积相关。观察数据来自学龄前儿童（时间点1：n = 35名儿童，3.9±0.5岁；6个月后：n = 28名儿童，4.5±0.5岁）。运动行为通过活动记录仪进行测量。结果指标为陈述性记忆和海马体亚区体积。多水平模型分别将运动行为作为绝对值进行探讨，并结合绝对总活动量、24小时睡眠时间和夜间睡眠效率进行分析。运动行为还在线性回归模型中作为组合因素进行探讨。在独立模型中，睡眠时间和中度至剧烈身体活动分别与总海马体体积和右侧海马体体积呈正相关。综合考虑时，符合睡眠建议的儿童更有可能拥有更大的总海马体体积、右侧和左侧半球、体部和尾部海马体体积。在我们的学龄前儿童样本中，我们观察到睡眠时间与海马体体积之间存在正相关，且与年龄无关。为了增进我们对幼儿期24小时行为与脑健康之间联系的理解，可能需要更大规模的样本，同时也考虑运动行为的背景和子成分。
