化疗与疫苗接种：一种控制高致病性流感病毒的可能策略。
Chemotherapy and vaccination: a possible strategy for the control of highly virulent influenza virus.
作者信息
Webster R G, Kawaoka Y, Bean W J, Beard C W, Brugh M
出版信息
J Virol. 1985 Jul;55(1):173-6. doi: 10.1128/JVI.55.1.173-176.1985.
Abstract
The influenza A virus [A/Chicken/Pennsylvania/1370/83 (H5N2)] that caused up to 80% mortality among chickens provided a model system for testing the efficacy of chemotherapeutic agents against highly virulent influenza virus. Amantadine and rimantadine administered in drinking water were efficacious both prophylactically and therapeutically. However, under conditions simulating natural transmission of virus, amantadine- and rimantadine-resistant viruses arose and were transmitted to other birds in contact with the infected chickens, causing mortality. Simultaneous administration of inactivated H5N2 vaccine and amantadine provided protection. Thus, chemotherapy may be useful in the treatment of a highly pathogenic influenza virus outbreak in humans or other animals when used in combination with vaccine.
摘要
甲型流感病毒[A/鸡/宾夕法尼亚/1370/83（H5N2）]在鸡群中造成了高达80%的死亡率，为测试化学治疗剂对抗高致病性流感病毒的疗效提供了一个模型系统。通过饮水给予金刚烷胺和金刚乙胺在预防和治疗方面均有效。然而，在模拟病毒自然传播的条件下，出现了对金刚烷胺和金刚乙胺耐药的病毒，并传播给了与感染鸡接触的其他禽类，导致死亡。同时接种灭活H5N2疫苗和金刚烷胺可提供保护。因此，化学疗法与疫苗联合使用时，可能对治疗人类或其他动物的高致病性流感病毒爆发有用。
相似文献
1
Chemotherapy and vaccination: a possible strategy for the control of highly virulent influenza virus.化疗与疫苗接种：一种控制高致病性流感病毒的可能策略。
J Virol. 1985 Jul;55(1):173-6. doi: 10.1128/JVI.55.1.173-176.1985.
2
Vaccination as a strategy to reduce the emergence of amantadine- and rimantadine-resistant strains of A/Chick/Pennsylvania/83 (H5N2) influenza virus.接种疫苗作为一种策略，以减少A/鸡/宾夕法尼亚/83（H5N2）流感病毒对金刚烷胺和金刚乙胺耐药毒株的出现。
J Antimicrob Chemother. 1986 Oct;18 Suppl B:157-64. doi: 10.1093/jac/18.supplement_b.157.
3
Biologic potential of amantadine-resistant influenza A virus in an avian model.金刚烷胺耐药甲型流感病毒在禽类模型中的生物学特性
J Infect Dis. 1989 Jun;159(6):1050-6. doi: 10.1093/infdis/159.6.1050.
4
Rimantadine hydrochloride and amantadine hydrochloride use in influenza A virus infections.盐酸金刚乙胺和盐酸金刚烷胺在甲型流感病毒感染中的应用。
Infect Dis Clin North Am. 1987 Jun;1(2):459-78.
5
Amantadine and rimantadine for the prevention of influenza A.金刚烷胺和金刚乙胺预防甲型流感
Semin Respir Infect. 1989 Dec;4(4):304-10.
6
Emergence of amantadine-resistant H5N2 avian influenza virus during a simulated layer flock treatment program.在模拟蛋鸡群治疗计划期间出现金刚烷胺耐药性H5N2禽流感病毒
Avian Dis. 1987 Jul-Sep;31(3):533-7.
7
Protection afforded by avian influenza vaccination programmes consisting of a novel RNA particle and an inactivated avian influenza vaccine against a highly pathogenic avian influenza virus challenge in layer chickens up to 18 weeks post-vaccination.新型 RNA 颗粒和灭活禽流感疫苗组成的禽流感疫苗接种方案对 18 周龄产蛋鸡接种高致病性禽流感病毒的保护作用。
Avian Pathol. 2019 Aug;48(4):371-381. doi: 10.1080/03079457.2019.1605148. Epub 2019 May 20.
8
Protection against virulent H5 avian influenza virus infection in chickens by an inactivated vaccine produced with recombinant vaccinia virus.用重组痘苗病毒生产的灭活疫苗对鸡抵抗强毒H5禽流感病毒感染的保护作用。
Vaccine. 1988 Jun;6(3):257-61. doi: 10.1016/0264-410x(88)90221-6.
9
Standardization of inactivated H5N2 influenza vaccine and efficacy against lethal A/Chicken/Pennsylvania/1370/83 infection.
Avian Dis. 1985 Jul-Sep;29(3):867-72.
10
引用本文的文献
1
Antiviral drugs in animal-derived matrices: A review.动物源基质中的抗病毒药物：综述
Heliyon. 2024 Sep 6;10(18):e37460. doi: 10.1016/j.heliyon.2024.e37460. eCollection 2024 Sep 30.
2
A single electroporation delivery of a DNA vaccine containing the hemagglutinin gene of Asian H5N1 avian influenza virus generated a protective antibody response in chickens against a North American virus strain.单次电穿孔递送含有亚洲H5N1禽流感病毒血凝素基因的DNA疫苗，在鸡体内产生了针对北美病毒株的保护性抗体反应。
Clin Vaccine Immunol. 2013 Apr;20(4):491-500. doi: 10.1128/CVI.00577-12. Epub 2013 Jan 30.
3
Insight into alternative approaches for control of avian influenza in poultry, with emphasis on highly pathogenic H5N1.了解控制家禽中禽流感的替代方法，重点是高致病性 H5N1。
Viruses. 2012 Nov 19;4(11):3179-208. doi: 10.3390/v4113179.
4
The influenza pandemic of 2009: lessons and implications.2009 年流感大流行：经验教训和启示。
Mol Diagn Ther. 2011 Apr 1;15(2):63-81. doi: 10.1007/BF03256397.
5
Paradox of vaccination: is vaccination really effective against avian flu epidemics?疫苗接种的悖论：疫苗接种对禽流感疫情真的有效吗？
PLoS One. 2009;4(3):e4915. doi: 10.1371/journal.pone.0004915. Epub 2009 Mar 18.
6
Utilization of the embryonated egg for in vivo evaluation of the anti-influenza virus activity of neuraminidase inhibitors.利用鸡胚对神经氨酸酶抑制剂的抗流感病毒活性进行体内评估。
Med Microbiol Immunol. 2006 Jun;195(2):65-71. doi: 10.1007/s00430-005-0002-x. Epub 2005 Jul 30.
7
Pandemic threat posed by avian influenza A viruses.甲型禽流感病毒构成的大流行威胁。
Clin Microbiol Rev. 2001 Jan;14(1):129-49. doi: 10.1128/CMR.14.1.129-149.2001.
8
Genetic basis of resistance to rimantadine emerging during treatment of influenza virus infection.流感病毒感染治疗期间出现的对金刚烷胺耐药性的遗传基础。
J Virol. 1988 May;62(5):1508-12. doi: 10.1128/JVI.62.5.1508-1512.1988.
9
Antiviral chemotherapy and prophylaxis of viral respiratory disease.抗病毒化疗与病毒性呼吸道疾病的预防
Clin Lab Med. 1987 Dec;7(4):869-96. doi: 10.1016/S0272-2712(18)30721-2.
10
Safety and prophylactic efficacy of low-dose rimantadine in adults during an influenza A epidemic.甲型流感流行期间低剂量金刚乙胺在成人中的安全性及预防效果
Antimicrob Agents Chemother. 1990 Sep;34(9):1633-6. doi: 10.1128/AAC.34.9.1633.
本文引用的文献
1
A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection.一项关于金刚烷胺和金刚乙胺预防甲型流感感染的对照试验。
N Engl J Med. 1982 Sep 2;307(10):580-4. doi: 10.1056/NEJM198209023071002.
2
Reactogenicity and immunogenicity of inactivated influenza A (H1N1) virus vaccine in unprimed children. Report to the Medical Research Council Committee on influenza and other respiratory virus vaccines.甲型流感（H1N1）病毒灭活疫苗在未接种过疫苗儿童中的反应原性和免疫原性。提交给医学研究委员会流感及其他呼吸道病毒疫苗委员会的报告。
J Biol Stand. 1980;8(1):35-48. doi: 10.1016/s0092-1157(80)80045-x.
3
Changes in the conformation of influenza virus hemagglutinin at the pH optimum of virus-mediated membrane fusion.在病毒介导的膜融合的最适pH值下流感病毒血凝素构象的变化
Proc Natl Acad Sci U S A. 1982 Feb;79(4):968-72. doi: 10.1073/pnas.79.4.968.
4
The standardization of inactivated equine influenza vaccines by single-radial immunodiffusion.
J Biol Stand. 1983 Apr;11(2):133-6. doi: 10.1016/s0092-1157(83)80037-7.
5
Failure to detect hemagglutination-inhibiting antibodies with intact avian influenza virions.未能检测到针对完整禽流感病毒粒子的血凝抑制抗体。
Infect Immun. 1982 Nov;38(2):530-5. doi: 10.1128/iai.38.2.530-535.1982.
6
Inhibition of uncoating of fowl plague virus by l-adamantanamine hydrochloride.盐酸L-金刚烷胺对鸡瘟病毒脱壳的抑制作用。
Virology. 1969 Apr;37(4):632-41. doi: 10.1016/0042-6822(69)90281-5.
7
Prevention of malignant avian influenza by 1-adamantanamine hydrochloride.
Arch Gesamte Virusforsch. 1970;32(2):171-84. doi: 10.1007/BF01249953.
8
In vivo selection of an influenza A2 strain resistant to amantadine.
Nature. 1970 Apr 4;226(5240):82-3. doi: 10.1038/226082a0.
9
New antigenic variants of avian influenza A viruses.甲型禽流感病毒的新抗原变体。
Bull World Health Organ. 1966;35(5):799-802.
10
Evaluation of amantadine in artificially induced A2 and B influenza.金刚烷胺在人工诱发甲型和乙型流感中的评估。
JAMA. 1970 Aug 31;213(9):1448-54.
Zotero 插件