Sato Rika, Naito Tateaki, Murakami Haruyasu, Omori Shota, Kobayashi Haruki, Ono Akira, Mamesaya Nobuaki, Wakuda Kazushige, Ko Ryo, Kenmotsu Hirotsugu, Aso Sakiko, Hasaba Miho, Mori Keita, Takahashi Toshiaki, Hayashi Naoko
Division of Nursing, Shizuoka Cancer Center, Shizuoka, Japan.
Graduate School of Nursing Science, St. Luke's International University, Tokyo, Japan.
Asia Pac J Oncol Nurs. 2025 Jan 23;12:100658. doi: 10.1016/j.apjon.2025.100658. eCollection 2025 Dec.
This study aimed to evaluate the association of cancer cachexia with psychosocial impact, nutrition impact symptoms (NIS), and geriatric assessment in older patients newly diagnosed with advanced lung cancer undergoing chemotherapy.
Older patients with advanced lung cancer scheduled to receive first-line chemotherapy between August 2021 and February 2022 were enrolled. Cachexia was diagnosed according to the International Consensus. NIS and psychosocial impacts were assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaires (EORTC QLQ) C30, CAX24, and the Eating-Related Distress Questionnaire (ERD). Non-parametric tests evaluated the association between cachexia and its impacts. Patients with cachexia who consented to be interviewed were asked about their experiences with diet and weight changes. Three authors reviewed the interview data to ensure the analysis's veracity.
Twenty-one of the 31 participants (68%) had cachexia at baseline. The cachexia group showed significantly greater severity of Food Aversion ( = 0.035), Eating and Weight Loss Worry ( < 0.001), and Loss of Control ( = 0.005) compared to the non-cachexia group. There were no significant differences in the ERD and geriatric assessment (all > 0.05). The interview revealed that patients with cachexia perceived diet and weight changes early on and tried to manage their symptoms by themselves.
Cancer cachexia showed an association with NIS and psychosocial impacts. Older patients with advanced lung cancer scheduled to receive first-line chemotherapy should undergo a comprehensive assessment of cancer cachexia, including its potential physical and psychological impacts.
The trial registration number was UMIN 000053843.
本研究旨在评估癌症恶病质与心理社会影响、营养影响症状（NIS）以及新诊断为晚期肺癌且正在接受化疗的老年患者的老年评估之间的关联。
纳入2021年8月至2022年2月期间计划接受一线化疗的老年晚期肺癌患者。根据国际共识诊断恶病质。使用欧洲癌症研究与治疗组织生活质量问卷（EORTC QLQ）C30、CAX24和饮食相关困扰问卷（ERD）评估NIS和心理社会影响。非参数检验评估恶病质与其影响之间的关联。对同意接受访谈的恶病质患者询问其饮食和体重变化经历。三位作者审查访谈数据以确保分析的准确性。
31名参与者中有21名（68%）在基线时患有恶病质。与非恶病质组相比，恶病质组在食物厌恶（P = 0.035）、饮食和体重减轻担忧（P < 0.001）以及失控感（P = 0.005）方面的严重程度明显更高。ERD和老年评估方面无显著差异（均P > 0.05）。访谈显示，恶病质患者早期就察觉到饮食和体重变化，并试图自行管理症状。
癌症恶病质与NIS和心理社会影响相关。计划接受一线化疗的老年晚期肺癌患者应接受癌症恶病质的综合评估，包括其潜在的生理和心理影响。
试验注册号为UMIN 000053843。
