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靶向致病性干扰素刺激基因RSAD2可改善系统性红斑狼疮模型中的妊娠结局。

Targeting pathogenic interferon-stimulated gene RSAD2 improves pregnancy outcomes in systemic lupus erythematosus models.

作者信息

Negatu Seble G, Jurado Kellie A

机构信息

Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

出版信息

Cell Rep Med. 2025 Mar 18;6(3):102034. doi: 10.1016/j.xcrm.2025.102034.

DOI:10.1016/j.xcrm.2025.102034
PMID:40107239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11970377/
Abstract

Excessive type I interferons during pregnancy are associated with poor pregnancy outcomes. Ding et al. demonstrate the pathogenic effects of the interferon-stimulated gene RSAD2 that drives adverse pregnancy outcomes through placental lipid accumulation, and further identify a promising therapeutic candidate.

摘要

孕期过量的I型干扰素与不良妊娠结局相关。丁等人证明了干扰素刺激基因RSAD2的致病作用，该基因通过胎盘脂质积累导致不良妊娠结局，并进一步确定了一个有前景的治疗候选物。

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本文引用的文献

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Cell Rep Med. 2025 Mar 18;6(3):101991. doi: 10.1016/j.xcrm.2025.101991. Epub 2025 Mar 6.
2
RSAD2: A pathogenic interferon-stimulated gene at the maternal-fetal interface of patients with systemic lupus erythematosus.RSAD2：系统性红斑狼疮患者母胎界面处的一个致病性干扰素刺激基因。
Cell Rep Med. 2025 Mar 18;6(3):101974. doi: 10.1016/j.xcrm.2025.101974. Epub 2025 Feb 20.
3
Systemic lupus erythematosus.系统性红斑狼疮。
Lancet. 2024 May 25;403(10441):2326-2338. doi: 10.1016/S0140-6736(24)00398-2. Epub 2024 Apr 17.
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GPER1 is required to protect fetal health from maternal inflammation.GPER1 对于保护胎儿健康免受母体炎症的影响是必需的。
Science. 2021 Jan 15;371(6526):271-276. doi: 10.1126/science.aba9001.
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IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise.IFITM 蛋白抑制胎盘合体滋养层的形成并促进胎儿死亡。
Science. 2019 Jul 12;365(6449):176-180. doi: 10.1126/science.aaw7733.
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Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development.妊娠和胎儿发育中的干扰素和促炎细胞因子。
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Type I interferons instigate fetal demise after Zika virus infection.寨卡病毒感染后 I 型干扰素引发胎儿死亡。
Sci Immunol. 2018 Jan 5;3(19). doi: 10.1126/sciimmunol.aao1680.
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Lupus activity in pregnancy.妊娠期狼疮活动
Rheum Dis Clin North Am. 2007 May;33(2):237-52, v. doi: 10.1016/j.rdc.2007.01.002.
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Early risk factors for pregnancy loss in lupus.狼疮患者妊娠丢失的早期危险因素
Obstet Gynecol. 2006 Feb;107(2 Pt 1):293-9. doi: 10.1097/01.AOG.0000194205.95870.86.
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Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection.目前用于人类免疫缺陷病毒（HIV）感染化疗的天然产物先导化合物。
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