靶向致病性干扰素刺激基因RSAD2可改善系统性红斑狼疮模型中的妊娠结局。
Targeting pathogenic interferon-stimulated gene RSAD2 improves pregnancy outcomes in systemic lupus erythematosus models.
作者信息
Negatu Seble G, Jurado Kellie A
机构信息
Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.
出版信息
Cell Rep Med. 2025 Mar 18;6(3):102034. doi: 10.1016/j.xcrm.2025.102034.
Abstract
Excessive type I interferons during pregnancy are associated with poor pregnancy outcomes. Ding et al. demonstrate the pathogenic effects of the interferon-stimulated gene RSAD2 that drives adverse pregnancy outcomes through placental lipid accumulation, and further identify a promising therapeutic candidate.
摘要
孕期过量的I型干扰素与不良妊娠结局相关。丁等人证明了干扰素刺激基因RSAD2的致病作用，该基因通过胎盘脂质积累导致不良妊娠结局，并进一步确定了一个有前景的治疗候选物。
相似文献
1
Targeting pathogenic interferon-stimulated gene RSAD2 improves pregnancy outcomes in systemic lupus erythematosus models.靶向致病性干扰素刺激基因RSAD2可改善系统性红斑狼疮模型中的妊娠结局。
Cell Rep Med. 2025 Mar 18;6(3):102034. doi: 10.1016/j.xcrm.2025.102034.
2
RSAD2: A pathogenic interferon-stimulated gene at the maternal-fetal interface of patients with systemic lupus erythematosus.RSAD2：系统性红斑狼疮患者母胎界面处的一个致病性干扰素刺激基因。
Cell Rep Med. 2025 Mar 18;6(3):101974. doi: 10.1016/j.xcrm.2025.101974. Epub 2025 Feb 20.
3
Cluster of highly expressed interferon-stimulated genes associate more with African ancestry than disease activity in patients with systemic lupus erythematosus. A systematic review of cross-sectional studies.高度表达的干扰素刺激基因簇与系统性红斑狼疮患者的非洲血统相关性高于疾病活动度。一项横断面研究的系统评价。
Transl Res. 2021 Dec;238:63-75. doi: 10.1016/j.trsl.2021.07.006. Epub 2021 Jul 31.
4
Protective and Pathogenic Effects of Interferon Signaling During Pregnancy.妊娠期干扰素信号的保护和致病作用。
Viral Immunol. 2020 Jan/Feb;33(1):3-11. doi: 10.1089/vim.2019.0076. Epub 2019 Sep 23.
5
Tissue Kallikrein-1 Suppresses Type I Interferon Responses and Reduces Depressive-Like Behavior in the MRL/lpr Lupus-Prone Mouse Model.组织激肽释放酶-1 抑制 I 型干扰素反应并减轻 MRL/lpr 狼疮易感小鼠模型的抑郁样行为。
Int J Mol Sci. 2024 Sep 19;25(18):10080. doi: 10.3390/ijms251810080.
6
Identification of key interferon-stimulated genes for indicating the condition of patients with systemic lupus erythematosus.鉴定干扰素刺激基因以指示系统性红斑狼疮患者的病情。
Front Immunol. 2022 Jul 28;13:962393. doi: 10.3389/fimmu.2022.962393. eCollection 2022.
7
EZH2 Inhibition Interferes With the Activation of Type I Interferon Signaling Pathway and Ameliorates Lupus Nephritis in NZB/NZW F1 Mice.EZH2 抑制干扰 I 型干扰素信号通路的激活并改善 NZB/NZW F1 小鼠的狼疮肾炎。
Front Immunol. 2021 Mar 26;12:653989. doi: 10.3389/fimmu.2021.653989. eCollection 2021.
8
Characterization of Type-I IFN subtype autoantibodies and activity in SLE serum and urine.SLE 血清和尿液中 I 型 IFN 亚型自身抗体的特征及活性。
Lupus. 2020 Aug;29(9):1095-1105. doi: 10.1177/0961203320935976. Epub 2020 Jul 1.
9
Signaling Pathways of Type I and Type III Interferons and Targeted Therapies in Systemic Lupus Erythematosus.I 型和 III 型干扰素的信号通路及在系统性红斑狼疮中的靶向治疗。
Cells. 2019 Aug 23;8(9):963. doi: 10.3390/cells8090963.
10
Pregnancy and interferon tau regulate RSAD2 and IFIH1 expression in the ovine uterus.妊娠和干扰素τ调节绵羊子宫中RSAD2和IFIH1的表达。
Reproduction. 2007 Jan;133(1):285-95. doi: 10.1530/REP-06-0092.
引用本文的文献
1
Viperin: A Multifunctional Protein in Antiviral Immunity and Disease Pathogenesis.蝰蛇毒蛋白：抗病毒免疫与疾病发病机制中的一种多功能蛋白。
Pathogens. 2025 May 21;14(5):510. doi: 10.3390/pathogens14050510.
本文引用的文献
1
Type I interferon exposure of an implantation-on-a-chip device alters invasive extravillous trophoblast function.芯片植入装置暴露于I型干扰素会改变侵袭性绒毛外滋养层细胞的功能。
Cell Rep Med. 2025 Mar 18;6(3):101991. doi: 10.1016/j.xcrm.2025.101991. Epub 2025 Mar 6.
2
RSAD2: A pathogenic interferon-stimulated gene at the maternal-fetal interface of patients with systemic lupus erythematosus.RSAD2：系统性红斑狼疮患者母胎界面处的一个致病性干扰素刺激基因。
Cell Rep Med. 2025 Mar 18;6(3):101974. doi: 10.1016/j.xcrm.2025.101974. Epub 2025 Feb 20.
3
Systemic lupus erythematosus.系统性红斑狼疮。
Lancet. 2024 May 25;403(10441):2326-2338. doi: 10.1016/S0140-6736(24)00398-2. Epub 2024 Apr 17.
4
GPER1 is required to protect fetal health from maternal inflammation.GPER1 对于保护胎儿健康免受母体炎症的影响是必需的。
Science. 2021 Jan 15;371(6526):271-276. doi: 10.1126/science.aba9001.
5
IFITM proteins inhibit placental syncytiotrophoblast formation and promote fetal demise.IFITM 蛋白抑制胎盘合体滋养层的形成并促进胎儿死亡。
Science. 2019 Jul 12;365(6449):176-180. doi: 10.1126/science.aaw7733.
6
Interferons and Proinflammatory Cytokines in Pregnancy and Fetal Development.妊娠和胎儿发育中的干扰素和促炎细胞因子。
Immunity. 2018 Sep 18;49(3):397-412. doi: 10.1016/j.immuni.2018.07.017.
7
Type I interferons instigate fetal demise after Zika virus infection.寨卡病毒感染后 I 型干扰素引发胎儿死亡。
Sci Immunol. 2018 Jan 5;3(19). doi: 10.1126/sciimmunol.aao1680.
8
Lupus activity in pregnancy.妊娠期狼疮活动
Rheum Dis Clin North Am. 2007 May;33(2):237-52, v. doi: 10.1016/j.rdc.2007.01.002.
9
Early risk factors for pregnancy loss in lupus.狼疮患者妊娠丢失的早期危险因素
Obstet Gynecol. 2006 Feb;107(2 Pt 1):293-9. doi: 10.1097/01.AOG.0000194205.95870.86.
10
Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection.目前用于人类免疫缺陷病毒（HIV）感染化疗的天然产物先导化合物。
Med Res Rev. 2000 Sep;20(5):323-49. doi: 10.1002/1098-1128(200009)20:5<323::aid-med1>3.0.co;2-a.
Zotero 插件