Wei Lijuan, Zhao Junyi, Zhong Yue, Wu Xiuqiao, Wei Shouhui, Liu Yiqing
Hubei key Laboratory of Spices & Horticultural Plant Germplasm Innovation & Utilization, College of Horticulture and Gardening, Yangtze University, Jingzhou 434025, China.
School of Marxism, Xi'an Jiaotong University, Xi'an 710049, China.
Int J Biol Macromol. 2025 May;307(Pt 3):142204. doi: 10.1016/j.ijbiomac.2025.142204. Epub 2025 Mar 17.
The free radical nitric oxide (NO) is an important redox-related signaling molecule modulating wide range of biological processes in all living plants. The transfer of NO bioactivity could be executed chiefly through a prototypic, redox-based post-translational modification, S-nitrosylation that covalently adds NO moiety to a reactive cysteine thiol of a target protein to form an S-nitrosothiol. Protein S-nitrosylation is recently emerged as an evolutionarily conserved and important mechanism regulating multiple aspects of plant growth and development. Here, we review the recent progress of S-nitrosylated proteins in the modulation of various plant development processes, including seed germination and aging, root development, seedling growth, flowering and fruit ripening and postharvest fruit quality. More importantly, the detailed function mechanism of proteins S-nitrosylation and key challenges in this field are also highlighted.
自由基一氧化氮（NO）是一种重要的与氧化还原相关的信号分子，可调节所有活植物体内广泛的生物过程。NO生物活性的传递主要可通过一种基于氧化还原的典型翻译后修饰——S-亚硝基化来实现，该修饰将NO基团共价添加到靶蛋白的反应性半胱氨酸硫醇上，形成S-亚硝基硫醇。蛋白质S-亚硝基化最近已成为一种在植物生长和发育的多个方面起调节作用的进化保守且重要的机制。在此，我们综述了S-亚硝基化蛋白在调节各种植物发育过程中的最新进展，包括种子萌发与衰老、根系发育、幼苗生长、开花与果实成熟以及采后果实品质。更重要的是，还强调了蛋白质S-亚硝基化的详细功能机制以及该领域的关键挑战。
