Kim Jiwoo, Cho Hyun Jeong, Kim Zisun, Youn Hyun Jo, Cho Jihyoung, Min Jun Won, Kim Yoo Seok, Lee Jung Eun
Department of Food and Nutrition, College of Human Ecology, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Republic of Korea.
Department of Surgery, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea.
Sci Rep. 2025 Mar 19;15(1):9481. doi: 10.1038/s41598-025-92951-4.
We investigated whether dietary intakes of saturated fat (SFA), monounsaturated fat (MUFA), or polyunsaturated fat (PUFA) were associated with plasma inflammatory markers among breast cancer survivors in Korea. This cross-sectional study included 419 female breast cancer survivors aged 30 to 78 years. Dietary intake was assessed using 3-day dietary records (DRs) or food frequency questionnaires (FFQs). Plasma levels of adiponectin, high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, IL-8, and tumor necrosis factor (TNF)-α were measured. We calculated an inflammatory composite score by summing the z-scores of each inflammatory marker, with adiponectin assigned a negative sign. Least-squares means (LS-means) and 95% confidence intervals (CIs) of inflammatory markers were estimated according to SFA, MUFA, and PUFA intakes using the generalized linear models. We found that increasing dietary MUFA intake was associated with increasing levels of adiponectin, but decreasing levels of hs-CRP (p for trend = 0.042 and 0.032, respectively). Similarly, higher dietary PUFA intake was associated with higher levels of adiponectin (p for trend = 0.023), but lower levels of hs-CRP and inflammatory composite score (p for trend < 0.001 and 0.036, respectively). However, no significant associations were found between SFA intake and plasma inflammatory markers. In conclusion, our results suggest that a higher intake of MUFA or PUFA is associated with a more favorable inflammatory profile among Korean female breast cancer survivors, which may potentially help in managing chronic inflammation.
我们调查了韩国乳腺癌幸存者的饱和脂肪（SFA）、单不饱和脂肪（MUFA）或多不饱和脂肪（PUFA）的饮食摄入量是否与血浆炎症标志物有关。这项横断面研究纳入了419名年龄在30至78岁之间的女性乳腺癌幸存者。使用3天饮食记录（DR）或食物频率问卷（FFQ）评估饮食摄入量。测量血浆脂联素、高敏C反应蛋白（hs-CRP）、白细胞介素（IL）-6、IL-8和肿瘤坏死因子（TNF）-α的水平。我们通过将每种炎症标志物的z分数相加来计算炎症综合评分，脂联素赋予负号。使用广义线性模型根据SFA、MUFA和PUFA摄入量估计炎症标志物的最小二乘均值（LS均值）和95%置信区间（CI）。我们发现，饮食中MUFA摄入量的增加与脂联素水平的升高有关，但与hs-CRP水平的降低有关（趋势p值分别为0.042和0.032）。同样，饮食中较高的PUFA摄入量与较高的脂联素水平有关（趋势p值为0.023），但与较低的hs-CRP和炎症综合评分有关（趋势p值分别<0.001和0.036）。然而，未发现SFA摄入量与血浆炎症标志物之间存在显著关联。总之，我们的结果表明，较高的MUFA或PUFA摄入量与韩国女性乳腺癌幸存者更有利的炎症特征相关，这可能有助于控制慢性炎症。
