Saeidpour Parizi Ali, Enhesari Ahmad, Moazed Vahid, Shafieipour Sara, Shahba Samira, Hermis Alaa Hamza, Zakeri Mohammad Ali
Gastroenterology and Hepatology Research Center, Kerman University of Medical Science, Kerman, Iran.
Clinical Research Development Unit, Afzalipour Hospital, Kerman University of Medical Science, Kerman, Iran.
J Med Case Rep. 2025 Mar 19;19(1):124. doi: 10.1186/s13256-025-05171-9.
Cervical esophageal adenocarcinoma is a rare tumor often associated with Barrett's esophagus, and its prevalence is lower than distal esophageal adenocarcinoma. Upper esophageal malignancies are usually squamous cell carcinomata; about 5% of these cases are seen during upper gastrointestinal endoscopy.
We present a patient (a 39-year-old Iranian man) with invasive adenocarcinoma of the proximal third of the esophagus, who was referred to the hospital with no endoscopic or histopathologic evidence of Barrett's esophagus. We discuss the probable cause of this tumor and treatment options and emphasize the importance of recognizing and managing this rare disease.
This case highlights the rarity of this adenocarcinoma and emphasizes the potential of chemotherapy as a standalone treatment, as well as the need for personalized therapeutic strategies and further research for the management of esophageal cancer.
颈段食管腺癌是一种罕见肿瘤，常与巴雷特食管相关，其发病率低于远端食管腺癌。上段食管恶性肿瘤通常为鳞状细胞癌；在上消化道内镜检查中约5%的病例为此类型。
我们报告一名患者（一名39岁的伊朗男性），患有食管近端三分之一处的浸润性腺癌，转诊至我院时并无巴雷特食管的内镜或组织病理学证据。我们讨论了该肿瘤可能的病因及治疗方案，并强调识别和管理这种罕见疾病的重要性。
本病例凸显了这种腺癌的罕见性，强调了化疗作为单一治疗手段的潜力，以及针对食管癌管理制定个性化治疗策略和进一步研究的必要性。
