Stupak Evgeny V, Glotov Vadim M, Askandaryan Arsen S, Clancy Sarah E, Hiana James C, Cherkasova Olga P, Stupak Vyacheslav V
Department of Neurosurgery, Novosibirsk Research Institute of Traumatology and Orthopedics n.a. Ya.L. Tsivyan, Novosibirsk, RUS.
Department of Psychiatry, St. John's Episcopal Hospital, New York, USA.
Cureus. 2025 Feb 17;17(2):e79165. doi: 10.7759/cureus.79165. eCollection 2025 Feb.
Raman spectroscopy (RS) is increasingly applied in medical fields to distinguish neoplastic from normal tissues, with recent advancements enabling its use in neurosurgery. This review explores RS as a diagnostic and surgical aid for brain gliomas, detailing its various modalities and applications. Through a comprehensive search in databases including PubMed, Google Scholar, and eLibrary, over 300 references were screened, resulting in 74 articles that met inclusion criteria. Key findings reveal RS's potential in neuro-oncology for examining native biopsy specimens, frozen and paraffin-embedded tissues, and body fluids, as well as performing intraoperative assessments. RS offers promise for identifying gliomas, differentiating them from healthy brain tissue, and establishing precise tumor boundaries during resection.
拉曼光谱（RS）在医学领域的应用日益广泛，用于区分肿瘤组织与正常组织，最近的进展使其能够应用于神经外科手术。本综述探讨了拉曼光谱作为脑胶质瘤诊断和手术辅助工具的作用，详细介绍了其各种模式和应用。通过在包括PubMed、谷歌学术和电子图书馆在内的数据库中进行全面检索，筛选了300多篇参考文献，最终有74篇文章符合纳入标准。主要研究结果表明，拉曼光谱在神经肿瘤学中具有潜力，可用于检查天然活检标本、冷冻和石蜡包埋组织以及体液，还可进行术中评估。拉曼光谱有望用于识别胶质瘤，将其与健康脑组织区分开来，并在切除过程中确定精确的肿瘤边界。
