安莎霉素的免疫抑制活性。
Immunosuppressant activity of the ansamycins.
作者信息
Kasik J E, Monick M, Thompson J S
出版信息
Antimicrob Agents Chemother. 1976 Mar;9(3):470-3. doi: 10.1128/AAC.9.3.470.
Abstract
The immunosuppressive effect of four analogues of rifampin and two streptovaracins on cell-mediated immunity has been determined. Tuberculin hypersensitivity in the footpads of immunized mice was inhibited by three of the rifampin analogues and by both streptovaracins. The observed in vivo immunosuppressive activity of the compounds tested was not correlated with their in vitro activity against mycobacterial growth but was associated with their toxicity in mice. These data indicate that some of the analogues of rifampin and the streptovaracins can significantly suppress cell-mediated immunity and suggest that other ansamycins may have significant immunosuppressant activity.
摘要
已测定了四种利福平类似物和两种链黑菌素对细胞介导免疫的免疫抑制作用。三种利福平类似物和两种链黑菌素均抑制了免疫小鼠足垫中的结核菌素超敏反应。所测试化合物在体内观察到的免疫抑制活性与其体外抗分枝杆菌生长的活性无关，但与其对小鼠的毒性有关。这些数据表明，一些利福平类似物和链黑菌素可显著抑制细胞介导的免疫，并提示其他安莎霉素可能具有显著的免疫抑制活性。
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本文引用的文献
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2
Rifampicin: a new rifamycin. II. Laboratory studies on the antituberculous activity and preliminary clinical observations.利福平：一种新型利福霉素。II. 抗结核活性的实验室研究及初步临床观察
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In vivo and in vitro suppression of humoral and cellular immunological response by rifampicin.利福平对体内和体外体液免疫及细胞免疫反应的抑制作用
Nature. 1970 Dec 19;228(5277):1188-90. doi: 10.1038/2281188a0.
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