Kasik J E, Monick M, Thompson J S
Antimicrob Agents Chemother. 1976 Mar;9(3):470-3. doi: 10.1128/AAC.9.3.470.
The immunosuppressive effect of four analogues of rifampin and two streptovaracins on cell-mediated immunity has been determined. Tuberculin hypersensitivity in the footpads of immunized mice was inhibited by three of the rifampin analogues and by both streptovaracins. The observed in vivo immunosuppressive activity of the compounds tested was not correlated with their in vitro activity against mycobacterial growth but was associated with their toxicity in mice. These data indicate that some of the analogues of rifampin and the streptovaracins can significantly suppress cell-mediated immunity and suggest that other ansamycins may have significant immunosuppressant activity.
已测定了四种利福平类似物和两种链黑菌素对细胞介导免疫的免疫抑制作用。三种利福平类似物和两种链黑菌素均抑制了免疫小鼠足垫中的结核菌素超敏反应。所测试化合物在体内观察到的免疫抑制活性与其体外抗分枝杆菌生长的活性无关,但与其对小鼠的毒性有关。这些数据表明,一些利福平类似物和链黑菌素可显著抑制细胞介导的免疫,并提示其他安莎霉素可能具有显著的免疫抑制活性。