影响范围：解决宿主-病毒相互作用的整体艺术。

mSphere of Influence: The integral art of resolving host-virus interactions.

作者信息

SoRelle Elliott D

机构信息

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

出版信息

mSphere. 2025 Apr 29;10(4):e0104024. doi: 10.1128/msphere.01040-24. Epub 2025 Mar 20.

DOI:10.1128/msphere.01040-24

PMID:40111039

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12039260/

Abstract

Elliott D. SoRelle studies viral infection and pathogenesis, specifically Epstein-Barr virus and its associated diseases, through the lens of single cell and spatial biology. In this mSphere of Influence article, he reflects on the essential value of art in biological research-and the frequent homology between the two. He incorporates themes from music and visual arts into a discussion of how three publications entitled "The cybernetics of development" by C. H. Waddington (, chapter 2, https://doi.org/10.4324/9781315765471), "Epstein-Barr viral productive amplification reprograms nuclear architecture, DNA replication, and histone deposition" by Y.-F. Chiu et al. (Cell Host Microbe 14:607-618, 2013, 10.1016/j.chom.2013.11.009), and "Comprehensive integration of single-cell data" by T. Stuart et al. (Cell 177:1888-1902.e21, 2019, https://doi.org/10.1016/j.cell.2019.05.031) shape his scientific perspectives in single-cell virology and provide a conceptual framework for dissecting multifaceted host-virus interactions.

摘要

埃利奥特·D·索雷尔通过单细胞和空间生物学的视角研究病毒感染与发病机制，特别是爱泼斯坦-巴尔病毒及其相关疾病。在这篇《mSphere影响力》文章中，他思考了艺术在生物学研究中的重要价值以及两者之间常见的同源性。他将音乐和视觉艺术的主题融入到对三篇论文的讨论中，这三篇论文分别是C. H. 沃丁顿所著的《发育的控制论》（第2章，https://doi.org/10.4324/9781315765471）、Y.-F. 邱等人所著的《爱泼斯坦-巴尔病毒的生产性扩增重编程核结构、DNA复制和组蛋白沉积》（《细胞宿主与微生物》14:607 - 618，2013，10.1016/j.chom.2013.11.009）以及T. 斯图尔特等人所著的《单细胞数据的全面整合》（《细胞》177:1888 - 1902.e21，2019，https://doi.org/10.1016/j.cell.2019.05.031），这些论文如何塑造了他在单细胞病毒学方面的科学观点，并为剖析多方面的宿主-病毒相互作用提供了一个概念框架。