Horkova Veronika, Everts Bart, Brenner Dirk
Experimental and Molecular Immunology, Department of Infection and Immunity (DII), Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
Immunology & Genetics, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Immunometabolism (Cobham). 2025 Mar 19;7(2):e00059. doi: 10.1097/IN9.0000000000000059. eCollection 2025 Apr.
In the last couple of decades, cancer research has been shifting its focus to the immune system. Cancer cells, with their ability to adapt and evade immune responses, seem to accelerate the evolutionary pressure that has been put on our immune system during evolution. We thus try to aid these natural selection processes and assist our immune system to combat cancer. Here, we are discussing a study by Greg Delgoffe and colleagues that was published in in December 2024, exploring a new approach to bring the dysfunctional immune cells back to life by blocking their lactate uptake.
在过去几十年里，癌症研究的重点一直在转向免疫系统。癌细胞具有适应和逃避免疫反应的能力，这似乎加剧了在进化过程中施加于我们免疫系统的进化压力。因此，我们试图助力这些自然选择过程，并协助我们的免疫系统对抗癌症。在此，我们正在讨论格雷格·德尔戈夫及其同事于2024年12月发表的一项研究，该研究探索了一种通过阻断功能失调的免疫细胞摄取乳酸来使其恢复活力的新方法。
