Rabaya Ali F, Ibraheem Kareem, Shawer Omar, Nairat Mutasem N, Sayes Sayf, Salhab Rafiq
Faculty of Medicine, Hebron University, Hebron, Palestine.
Faculty of Medicine, Palestine Polytechnic University, Hebron 90200, Palestine; Palestinian Clinical Research Center, Bethlehem, Palestine.
Int J Surg Case Rep. 2025 Apr;129:111172. doi: 10.1016/j.ijscr.2025.111172. Epub 2025 Mar 18.
Polyarteritis Nodosa (PAN) is a rare vasculitis of medium-sized arteries with severe complications, including Renal artery aneurysm (RAA)rupture and gastrointestinal ischemia. Early recognition and intervention are crucial for improving outcomes.
A 21-year-old male with a history of PAN presented with acute flank pain, rash, confusion, and anemia. Imaging revealed a ruptured RAA with retroperitoneal hemorrhage. He developed bowel ischemia confirmed by colonoscopy and computed tomography scan. The patient underwent renal artery embolization and exploratory laparotomy, revealing gangrenous cecum and ileal perforation, requiring hemicolectomy and ileal resection. Postoperatively, he was treated with immunoglobulin, cyclophosphamide, and prednisone, resulting in significant improvement.
PAN can cause life-threatening complications, including vascular rupture and ischemia. Embolization effectively controlled bleeding, and surgery addressed ischemic damage. Early intervention with immunosuppressive therapy played a key role in recovery.
This case emphasizes the need for prompt recognition and treatment of severe PAN complications. Early surgical intervention and appropriate immunosuppressive therapy are essential for preventing fatal outcomes.
结节性多动脉炎(PAN)是一种累及中等大小动脉的罕见血管炎,可导致严重并发症,包括肾动脉瘤(RAA)破裂和胃肠道缺血。早期识别和干预对于改善预后至关重要。
一名有PAN病史的21岁男性,出现急性侧腹痛、皮疹、意识模糊和贫血。影像学检查显示RAA破裂并伴有腹膜后出血。结肠镜检查和计算机断层扫描证实他出现了肠道缺血。患者接受了肾动脉栓塞术和剖腹探查术,发现盲肠坏疽和回肠穿孔,需要进行半结肠切除术和回肠切除术。术后,他接受了免疫球蛋白、环磷酰胺和泼尼松治疗,病情显著改善。
PAN可导致危及生命的并发症,包括血管破裂和缺血。栓塞术有效控制了出血,手术解决了缺血性损伤。早期采用免疫抑制治疗在康复中起关键作用。
本病例强调了对严重PAN并发症进行及时识别和治疗的必要性。早期手术干预和适当的免疫抑制治疗对于预防致命后果至关重要。