Özkan Yaprak, Gökçınar Nesrin Büyüktortop
Department of Ophthalmology, Çorum Education and Research Hospital, Hitit University, Çorum, Turkey.
Department of Ophthalmology, Ankara Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.
Int Ophthalmol. 2025 Mar 22;45(1):121. doi: 10.1007/s10792-025-03474-w.
To assess the repeatability and agreement of anterior segment measurements obtained using a partial coherence interferometry-based optical biometry device (AL-Scan) and a combined Scheimpflug-Placido disc corneal topography device (Sirius) in keratoconic and control eyes.
Central corneal thickness (CCT), anterior chamber depth (ACD), white-to-white distance (WTW), and keratometry values were measured in keratoconic and control eyes using the AL-Scan and Sirius. The agreement, repeatability, and reliability of the measurements were analyzed.
The study included 82 keratoconus patients (82 eyes) and 100 healthy subjects (100 eyes). The mean CCT and ACD values measured by Sirius were significantly higher than those measured by AL-Scan in both groups (p < 0.001). WTW measurements did not differ significantly between devices (p > 0.05). In control eyes, keratometric values showed no significant differences between devices, whereas in keratoconic eyes, almost all keratometric values were significantly different. Reliability was excellent for all parameters in both devices (intra-class correlation coefficient [ICC] > 0.9). Repeatability was excellent for all parameters in both devices (coefficient of variation [CoV] < 1%), except for CCT in keratoconic eyes (CoV < 3%). CONCLUSıONS: Both the AL-Scan and Sirius provide highly repeatable and reliable measurements in both healthy and keratoconic eyes. However, in keratoconic eyes, agreement between the two devices is poor for all parameters except WTW.
评估在圆锥角膜眼和对照眼中，使用基于部分相干干涉测量法的光学生物测量设备（AL-Scan）和联合的Scheimpflug-普拉西多盘角膜地形图设备（Sirius）获得的眼前节测量值的可重复性和一致性。
使用AL-Scan和Sirius测量圆锥角膜眼和对照眼中的中央角膜厚度（CCT）、前房深度（ACD）、白对白距离（WTW）和角膜曲率值。分析测量值的一致性、可重复性和可靠性。
该研究纳入了82例圆锥角膜患者（82只眼）和100名健康受试者（100只眼）。在两组中，Sirius测量的平均CCT和ACD值均显著高于AL-Scan测量的值（p < 0.001）。设备之间的WTW测量值无显著差异（p > 0.05）。在对照眼中，设备之间的角膜曲率值无显著差异，而在圆锥角膜眼中，几乎所有角膜曲率值均有显著差异。两种设备所有参数的可靠性均极佳（组内相关系数[ICC] > 0.9）。两种设备所有参数的可重复性均极佳（变异系数[CoV] < 1%），圆锥角膜眼中的CCT除外（CoV < 3%）。结论：AL-Scan和Sirius在健康眼和圆锥角膜眼中均能提供高度可重复且可靠的测量值。然而，在圆锥角膜眼中，除WTW外，两种设备在所有参数上的一致性均较差。
