Department of Ophthalmology, Faculty of Medicine, Excellence Center for Cornea and Limbal Stem Cell Transplantation, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, Thailand.
Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
PLoS One. 2022 May 24;17(5):e0268856. doi: 10.1371/journal.pone.0268856. eCollection 2022.
To evaluate agreement of total corneal power (TCP) measured by swept-source anterior segment optical coherence tomography (CASIA 2), Scheimpflug tomography (Pentacam AXL), and swept-source optical biometer (IOLMaster 700) in normal and keratoconic patients.
This is a prospective observational study conducted at King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Biometric values were measured by each device for three times by two operators to evaluate repeatability and reproducibility of TCP. The agreement of TCP and other parameters including total corneal astigmatism, anterior keratometry, anterior corneal astigmatism, posterior keratometry, posterior corneal astigmatism, anterior chamber depth, white-to-white corneal diameter (WTW), central corneal thickness, and intraocular power were also evaluated.
This study enrolled 100 healthy participants and 34 patients with keratoconus. The repeatability and reproducibility of TCP were high in all devices (ICC > 0.9). The agreement of TCP was excellent among three devices in both groups (ICC > 0.9). However, the agreement of TCP between CASIA 2 and IOLMaster 700 was slightly lower in healthy participants (ICC = 0.867) and keratoconic patients (ICC = 0.852) with mean differences of more than 1.0 diopter is clinically significant. Wider 95% limit of agreement were found in keratoconic eyes. Most of other parameters showed good to excellent agreement except WTW which showed poor to moderate agreement in both groups. IOL power showed clinically significant differences in patients with keratoconus.
The agreement of TCP measured by three devices was excellent in normal and keratoconic patients. However, TCP cannot be used interchangeably between devices.
评估使用扫频源眼前节光学相干断层扫描仪（CASIA 2）、Scheimpflug 断层扫描仪（Pentacam AXL）和扫频光生物测量仪（IOLMaster 700）测量正常和圆锥角膜患者的总角膜屈光力（TCP）的一致性。
这是在泰国曼谷朱拉隆功国王纪念医院进行的一项前瞻性观察性研究。由两名操作人员使用每种设备测量三次生物测量值，以评估 TCP 的重复性和再现性。还评估了 TCP 与其他参数（包括总角膜散光、前角膜曲率、前角膜散光、后角膜曲率、后角膜散光、前房深度、角膜直径（WTW）、中央角膜厚度和眼内屈光力）的一致性。
本研究纳入了 100 名健康参与者和 34 名圆锥角膜患者。所有设备的 TCP 重复性和再现性均较高（ICC > 0.9）。在两组中，三种设备的 TCP 一致性均非常好（ICC > 0.9）。然而，在健康参与者（ICC = 0.867）和圆锥角膜患者（ICC = 0.852）中，CASIA 2 和 IOLMaster 700 之间的 TCP 一致性略低，差异平均值超过 1.0 屈光度在临床上具有重要意义。在圆锥角膜眼中发现了更宽的 95%一致性界限。除了 WTW 在两组中显示出较差到中度的一致性外，大多数其他参数显示出良好到极好的一致性。在圆锥角膜患者中，IOL 屈光力显示出明显的差异。
在正常和圆锥角膜患者中，三种设备测量的 TCP 一致性非常好。然而，设备之间不能互换使用 TCP。
