Barajas-Torres G-C, Villanueva-Moreno N-L, Rincón-Rodríguez H, Cuairán-Ruidiaz V, Márquez-González H, Murillo-Eliosa J-R, Mosqueda-Taylor A
Health Care Department Univ. Autónoma Metropolitana Xochimilco Calzada del Hueso 1100 Villa Quietud, Coyoacán C.P. 04960 México City, México
Med Oral Patol Oral Cir Bucal. 2025 Jul 1;30(4):e476-e483. doi: 10.4317/medoral.27021.
Myofibromas are infrequent neoplasms that rarely occur in the jawbones. The aim of this study is to present a series of cases of these tumors affecting the jawbones in pediatric patients, as well as to describe their diagnostic methodology and therapeutic approach.
retrospective study of a series of myofibromas of the jawbones diagnosed and treated in a single medical institution in Mexico City from 2002-2022.
There were 14 cases with a median age of 6.5 years (IQR:1-12). Mandible was affected in 8 cases (57.1%), maxilla in 5 (35.8%) and only one case (7.1%) occurred in both jaws. Microscopically, the lesions were composed predominantly by spindle cells, as well as stellate and sometimes pleomorphic in shape, most of which were positive for smooth muscle actin. All cases were treated with complete excision of the lesion and only one presented recurrence.
Once the diagnosis is confirmed and other spindle cell neoplasms have been excluded, resection with free margins represents the treatment of choice.
肌纤维瘤是一种罕见的肿瘤，很少发生于颌骨。本研究的目的是报告一系列发生于儿童患者颌骨的此类肿瘤病例，并描述其诊断方法和治疗方式。
对2002年至2022年在墨西哥城一家医疗机构诊断并治疗的一系列颌骨肌纤维瘤进行回顾性研究。
共14例，中位年龄6.5岁（四分位间距：1 - 12岁）。下颌骨受累8例（57.1%），上颌骨受累5例（35.8%），仅1例（7.1%）双侧颌骨均有病变。显微镜下，病变主要由梭形细胞组成，还有星状细胞，有时形态多样，其中大多数平滑肌肌动蛋白呈阳性。所有病例均采用病变完整切除治疗，仅1例复发。
一旦确诊并排除其他梭形细胞肿瘤，切缘阴性的切除术是首选治疗方法。
