补充益生菌对非传染性疾病炎症和氧化应激生物标志物的缓解作用：采用GRADE方法的系统评价和荟萃分析
Alleviating effects of probiotic supplementation on biomarkers of inflammation and oxidative stress in non-communicable diseases: a systematic review and meta-analysis using the GRADE approach.
作者信息
Yu Xiaoyuan, Yan Li, Chen Lingxiao, Shen Xianmei, Zhang Wenzheng
机构信息
Emergency and Critical Care Center, Intensive Care Unit, Affiliated People's Hospital, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Department of Geriatric Gastroenterology, Nanjing Medical University, Nanjing, China.
出版信息
BMC Pharmacol Toxicol. 2025 Jul 1;26(1):124. doi: 10.1186/s40360-025-00957-5.
BACKGROUND
Inflammation and oxidative stress are key risk factors in noncommunicable diseases (NCDs). Probiotics have been suggested to be beneficial in mitigating inflammation and oxidative stress; however, the evidence remains inconsistent due to variations in study design, dosage, and patient populations.
METHODS
Studies were included following a systematic search of PubMed, Scopus, Cochrane Library, Web of Science, and EMBASE, provided they fulfilled the eligibility criteria. This systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to clarify the effects of probiotics on oxidative stress and inflammation in non-communicable diseases (NCDs).
RESULTS
A review of 18 studies revealed that probiotic supplementation significantly reduced CRP (SMD = -1.33, 95% CI: -1.84, -0.82; p < 0.001, high certainty), TNF-α (SMD = -1.10, 95% CI: -1.66, -0.55; p < 0.001, low certainty), and MDA levels (SMD = -1.38, 95% CI: -2.08, -0.69; p < 0.001, high certainty). Additionally, while probiotics increased GSH levels (SMD = 0.65, 95% CI: 0.06, 1.23; p < 0.001, high certainty), they did not change the levels of IL-6 (SMD = -1.05, 95% CI: -2.21, 0.11; p < 0.001, low certainty), NO (SMD = 0.47, 95% CI: -0.54, 1.48; p = 0.363, low certainty) and TAC levels (SMD = 0.24, 95% CI: -0.27, 0.74; p = 0.357, moderate certainty).
CONCLUSION
The supplementation of probiotics may have mitigated biomarkers associated with inflammation and oxidative stress.
背景
炎症和氧化应激是非传染性疾病（NCDs）的关键风险因素。已表明益生菌有助于减轻炎症和氧化应激；然而，由于研究设计、剂量和患者群体的差异，证据仍然不一致。
方法
在对PubMed、Scopus、Cochrane图书馆、科学网和EMBASE进行系统检索后纳入研究，前提是它们符合纳入标准。这项对随机对照试验（RCTs）的系统评价和荟萃分析旨在阐明益生菌对非传染性疾病（NCDs）中氧化应激和炎症的影响。
结果
对18项研究的综述显示，补充益生菌显著降低了CRP（标准化均数差[SMD]=-1.33，95%置信区间[CI]：-1.84，-0.82；p<0.001，高确定性）、TNF-α（SMD=-1.10，95%CI：-1.66，-0.55；p<0.001，低确定性）和丙二醛（MDA）水平（SMD=-1.38，95%CI：-2.08，-0.69；p<0.001，高确定性）。此外，虽然益生菌增加了谷胱甘肽（GSH）水平（SMD=0.65，95%CI：0.06，1.23；p<0.001，高确定性），但它们并未改变白细胞介素-6（IL-6）水平（SMD=-1.05，95%CI：-2.21，0.11；p<0.001，低确定性）、一氧化氮（NO）水平（SMD=0.47，95%CI：-0.54，1.48；p=0.363，低确定性）和总抗氧化能力（TAC）水平（SMD=0.24，95%CI：-0.27，0.74；p=0.357，中等确定性）。
结论
补充益生菌可能减轻了与炎症和氧化应激相关的生物标志物。
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