Huang Yuhan, Wang Kaiyuan, Wang Wenjing, Sun Xueqian, Zhao Shihao, Miao Yuanyuan, Tao Yuchun, Jin Lina
Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Jilin, Changchun, China.
Diabetes Res Clin Pract. 2025 May;223:112128. doi: 10.1016/j.diabres.2025.112128. Epub 2025 Mar 22.
Overactive bladder (OAB) is a syndrome marked by urinary urgency. Given the crucial role of metabolic anomalies in the pathogenesis of OAB, the aim of this study was to investigate the associations between different triglyceride glucose index (TyG)-related indicators and OAB.
9024 participants aged ≥ 20 years from NHANES 2005-2018 were involved. Weighted multivariate logistic regression was employed to assess the relationship between three TyG-related indicators and OAB with subgroup and interaction analyses. In addition, ROC, DeLong's test and confusion matrix were further utilized to assess the predictive power of different indicators for OAB in the total population versus different subgroups of the population.
TyG-related indicators were positively associated with OAB. The associations were statistically different in age and physical activity subgroups (all p for interaction < 0.1). In the whole population, TyG-WHtR demonstrated the highest predictive ability, with the largest AUC of 0.625 (95 %CI: 0.609, 0.641), and was relatively more predictive in the < 60 years and moderate-to-vigorous physical activity subgroups.
Positive associations of TyG-related indicators with OAB were observed. TyG-WHtR has the strongest predictive performance for OAB in the total population.
膀胱过度活动症（OAB）是一种以尿急为特征的综合征。鉴于代谢异常在OAB发病机制中的关键作用，本研究旨在探讨不同甘油三酯葡萄糖指数（TyG）相关指标与OAB之间的关联。
纳入了来自2005 - 2018年美国国家健康与营养检查调查（NHANES）的9024名年龄≥20岁的参与者。采用加权多因素逻辑回归评估三个TyG相关指标与OAB之间的关系，并进行亚组分析和交互作用分析。此外，进一步利用受试者工作特征曲线（ROC）、德龙检验（DeLong's test）和混淆矩阵评估不同指标在总体人群与不同亚组人群中对OAB的预测能力。
TyG相关指标与OAB呈正相关。在年龄和身体活动亚组中，这种关联在统计学上存在差异（所有交互作用p值均<0.1）。在总体人群中，TyG - 腰围身高比（TyG - WHtR）表现出最高的预测能力，最大曲线下面积（AUC）为0.625（95%置信区间：0.609，0.641），并且在<60岁和中度至剧烈身体活动亚组中预测性相对更强。
观察到TyG相关指标与OAB呈正相关。TyG - WHtR在总体人群中对OAB具有最强的预测性能。
