Zhang Xiaotong, Liu Min, Wang Yuping, Zheng Ya, Zhou Yongning
The First Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.
BMC Public Health. 2025 Mar 24;25(1):1126. doi: 10.1186/s12889-025-22265-7.
The consumption of sugar-sweetened beverages (SSBs) has increased substantially over recent decades, raising concerns about its various physiological effects on bodily function. However, the relationship between SSBs intake and constipation remains insufficiently understood.
Data from 7,979 participants sourced from the National Health and Nutrition Examination Survey (NHANES) were analyzed in this study. Dietary intake of SSBs was assessed using two 24-hour dietary recall interviews, and constipation was defined according to the Bristol Stool Form Scale (BSFS) Cards. We employed weighted logistic regression analysis to examine the relationship between SSBs consumption (quantified in grams and kilocalories) and the risk of constipation, while stratified and restricted cubic spline (RCS) analyses explored population variability.
After adjusting for all relevant variables, SSBs quantified in grams (SSBs-grams) (OR vs. = 1.419, 95% CI: 1.064-1.893, p = 0.019; p for trend = 0.02) and SSBs quantified in kilocalories (SSBs-kcal) (OR vs. = 1.567, 95% CI: 1.100-2.234, p = 0.015; p for trend = 0.016) showed a significant positive association with constipation. Furthermore, the weighted RCS and stratified analyses indicated that the association varied among subgroups, with a non-linear relationship between SSBs-kcal and constipation (SSBs-grams: p non-linear = 0.100, SSBs-kcal: p non-linear = 0.026).
Our findings indicated that increased SSBs consumption is associated with a higher risk of constipation. The results underscore the need for public health interventions aimed at reducing the intake of SSBs and promoting healthier alternatives.
在最近几十年里，含糖饮料（SSB）的消费量大幅增加，这引发了人们对其对身体功能的各种生理影响的担忧。然而，SSB摄入量与便秘之间的关系仍未得到充分理解。
本研究分析了来自美国国家健康与营养检查调查（NHANES）的7979名参与者的数据。通过两次24小时饮食回顾访谈评估SSB的饮食摄入量，并根据布里斯托大便分类法（BSFS）卡片定义便秘。我们采用加权逻辑回归分析来研究SSB消费量（以克和千卡为单位）与便秘风险之间的关系，同时进行分层和受限立方样条（RCS）分析以探索人群变异性。
在对所有相关变量进行调整后，以克为单位量化的SSB（SSB-克）（比值比[OR]与最低四分位数相比 = 1.419，95%置信区间[CI]：1.064 - 1.893，p = 0.019；趋势p值 = 0.02）和以千卡为单位量化的SSB（SSB-千卡）（OR与最低四分位数相比 = 1.567，95% CI：1.100 - 2.234，p = 0.015；趋势p值 = 0.016）与便秘呈显著正相关。此外，加权RCS和分层分析表明，这种关联在亚组之间存在差异，SSB-千卡与便秘之间存在非线性关系（SSB-克：非线性p值 = 0.100，SSB-千卡：非线性p值 = 0.026）。
我们的研究结果表明，SSB消费量增加与便秘风险较高有关。这些结果强调了需要采取公共卫生干预措施，以减少SSB的摄入量并推广更健康的替代品。
