具有相反极性的微管马达在货物运输中相互协作而非竞争。
Microtubule motors of opposite polarity cooperate rather than compete in cargo transport.
作者信息
Markus Steven M
机构信息
Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.
出版信息
Nat Struct Mol Biol. 2025 Apr;32(4):595-597. doi: 10.1038/s41594-025-01524-6.
Abstract
Microtubule-based cargo transport relies on the actions of dynein and kinesins, motors that walk in opposite directions yet act together to ensure appropriate distribution of cargos in cells. Research now provides mechanistic insights into how these seemingly antagonistic motors collaborate, rather than compete, to promote each other’s activities.
摘要
基于微管的货物运输依赖于动力蛋白和驱动蛋白的作用，这些分子马达沿相反方向移动，但共同作用以确保货物在细胞中的适当分布。现在的研究提供了关于这些看似相互拮抗的分子马达如何协作而非竞争以促进彼此活性的机制性见解。
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本文引用的文献
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Nat Struct Mol Biol. 2025 Apr;32(4):756-766. doi: 10.1038/s41594-024-01418-z. Epub 2025 Jan 2.
2
TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport.TRAK 衔接蛋白调节线粒体运输中动力蛋白和驱动蛋白的募集和激活。
Nat Commun. 2023 Mar 13;14(1):1376. doi: 10.1038/s41467-023-36945-8.
3
Mitochondrial adaptor TRAK2 activates and functionally links opposing kinesin and dynein motors.线粒体衔接蛋白 TRAK2 激活并功能连接相反的驱动蛋白和动力蛋白。
Nat Commun. 2021 Jul 28;12(1):4578. doi: 10.1038/s41467-021-24862-7.
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A Combinatorial MAP Code Dictates Polarized Microtubule Transport.组合性 MAP 码决定极化微管运输。
Dev Cell. 2020 Apr 6;53(1):60-72.e4. doi: 10.1016/j.devcel.2020.01.029. Epub 2020 Feb 27.
5
Hook3 is a scaffold for the opposite-polarity microtubule-based motors cytoplasmic dynein-1 and KIF1C.Hook3 是一种支架，用于相反极性的微管基马达细胞质动力蛋白-1 和 KIF1C。
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