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New strategy against sperm oxidative damage: supplementing NaHS to enhance the activity of the HS antioxidant pathway mediated by E3 ubiquitin ligase ASB1.

作者信息

Zhou Nianchao, Liu Mingxi, Shang Xuejun

机构信息

Human Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University Wuxi 214062, Jiangsu, China.

State Key Laboratory of Reproductive Medicine and Offspring Health, Department of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University Nanjing 211166, Jiangsu, China.

出版信息

Am J Clin Exp Immunol. 2025 Feb 25;14(1):43-44. doi: 10.62347/LZHL6737. eCollection 2025.

DOI:10.62347/LZHL6737
PMID:40134824
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11932064/
Abstract
摘要

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本文引用的文献

1
ASB1 engages with ELOB to facilitate SQOR ubiquitination and HS homeostasis during spermiogenesis.在精子发生过程中，ASB1与ELOB相互作用，以促进SQOR泛素化和血红素加氧酶系统稳态。
Redox Biol. 2025 Feb;79:103484. doi: 10.1016/j.redox.2024.103484. Epub 2024 Dec 27.
2
An essential role of the E3 ubiquitin ligase RNF126 in ensuring meiosis I completion during spermatogenesis.E3泛素连接酶RNF126在确保精子发生过程中减数分裂I完成方面的重要作用。
J Adv Res. 2025 Jul;73:231-245. doi: 10.1016/j.jare.2024.08.011. Epub 2024 Aug 12.
3
E3 ubiquitin ligase RNF187 promotes growth of spermatogonia via lysine 48-linked polyubiquitination-mediated degradation of KRT36/KRT84.E3 泛素连接酶 RNF187 通过赖氨酸 48 连接的多泛素化介导的 KRT36/KRT84 降解促进精原细胞的生长。
FASEB J. 2023 Oct;37(10):e23217. doi: 10.1096/fj.202301120R.
4
The ubiquitin codes in cellular stress responses.泛素码在细胞应激反应中的作用。
Protein Cell. 2024 Feb 29;15(3):157-190. doi: 10.1093/procel/pwad045.
5
Male Infertility Coexists with Decreased Sperm Genomic Integrity and Oxidative Stress in Semen Irrespective of Leukocytospermia.无论是否存在白细胞精子症，男性不育都与精子基因组完整性降低和精液中的氧化应激并存。
Antioxidants (Basel). 2022 Oct 5;11(10):1987. doi: 10.3390/antiox11101987.
6
Hydrogen Sulfide Oxidation by Sulfide Quinone Oxidoreductase.硫化物醌氧化还原酶催化的硫化氢氧化。
Chembiochem. 2021 Mar 16;22(6):949-960. doi: 10.1002/cbic.202000661. Epub 2020 Nov 17.
7
Oxidative stress and male infertility.氧化应激与男性不育。
Nat Rev Urol. 2017 Aug;14(8):470-485. doi: 10.1038/nrurol.2017.69. Epub 2017 May 16.
8
The role of E3 ligases in the ubiquitin-dependent regulation of spermatogenesis.E3 泛素连接酶在精子发生的泛素依赖性调控中的作用。
Semin Cell Dev Biol. 2014 Jun;30:27-35. doi: 10.1016/j.semcdb.2014.03.001. Epub 2014 Mar 12.
9
H₂S signalling through protein sulfhydration and beyond.硫化氢通过蛋白质巯基化的信号转导及其他途径。
Nat Rev Mol Cell Biol. 2012 Jul 11;13(8):499-507. doi: 10.1038/nrm3391.
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Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling.细胞信号转导中的活性氧（ROS）稳态和氧化还原调节。
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