Huang Junjie, Yim Lai, Sawhney Apurva, Lok Veeleah, Zhang Lin, Lin Xu, Lucero-Prisno Don Eliseo, Zhong Claire Chenwen, Xu Wanghong, Zheng Zhi-Jie, Withers Mellissa, Wong Martin C S
The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong SAR, China.
Centre for Health Education and Health Promotion, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Brain Behav. 2025 Mar;15(3):e70430. doi: 10.1002/brb3.70430.
Malignant meningioma is a rare form of primary central nervous system cancer originating from the meninges membrane layers. Current data remain unmapped to cover trends for particular groups globally.
This study examined the missing gap for its global burden, country-specific incidence, and risk factor trends, stratified by sex and age. Several databases were retrieved for temporal trend analysis and interpretation: Cancer incidence rates from five continents (CI5 Plus), global cancer observatory (GLOBOCAN), global burden of disease (GBD), and the world bank. association between malignant meningioma's and various factors was determined using linear regression. Meningioma incidence trends were estimated using the average annual percentage change (AAPC) with join point regression, including the shift in cancerous meningioma incidence based on corresponding specific variables.
New malignant meningioma cases reported in 2020 were estimated to be 14,832 with aged-standardized rates (ASR) of 1.3 per million population. Considerable variations exist among nations for malignant meningioma's, with the highest ASR found in Latvia (6.9 per million population), compared to a 345-fold difference from the lowest ASR found in Fiji (0.02 per million population). Additionally, chronic disease presence such as smoking and hypertension was associated with higher malignant meningioma incidence. The analysis observed increasing rates of malignant meningioma in younger populations.
Overall, this study contributes a global perspective on malignant meningioma incidence and emphasizes further investigation of specific groups that may have been overlooked. The increasing trend of malignant meningioma in younger populations warrants preventive, early diagnosis, and further research initiatives for evidence on risk management.
恶性脑膜瘤是一种罕见的原发性中枢神经系统癌症，起源于脑膜层。目前的数据尚未涵盖全球特定人群的趋势。
本研究调查了其全球负担、特定国家发病率和风险因素趋势方面的缺失差距，并按性别和年龄进行分层。检索了几个数据库进行时间趋势分析和解读：来自五大洲的癌症发病率（CI5 Plus）、全球癌症观测站（GLOBOCAN）、全球疾病负担（GBD）和世界银行。使用线性回归确定恶性脑膜瘤与各种因素之间的关联。使用平均年度百分比变化（AAPC）和连接点回归估计脑膜瘤发病率趋势，包括基于相应特定变量的癌性脑膜瘤发病率变化。
2020年报告的新恶性脑膜瘤病例估计为14,832例，年龄标准化发病率（ASR）为每百万人口1.3例。各国之间恶性脑膜瘤的发病率存在相当大的差异，拉脱维亚的ASR最高（每百万人口6.9例），而斐济的ASR最低（每百万人口0.02例），两者相差345倍。此外，吸烟和高血压等慢性病与较高的恶性脑膜瘤发病率相关。分析观察到年轻人群中恶性脑膜瘤的发病率在上升。
总体而言，本研究提供了关于恶性脑膜瘤发病率的全球视角，并强调对可能被忽视的特定人群进行进一步调查。年轻人群中恶性脑膜瘤发病率的上升趋势值得开展预防、早期诊断以及进一步的研究举措以获取风险管理证据。
