Santos Priscila Portugal Dos, Fujimori Anderson Seiji Soares, Polegato Bertha Furlan, Okoshi Marina Politi
Internal Medicine Department, Botucatu Medical School, Sao Paulo State University (UNESP), Botucatu 18618-687, Brazil.
Metabolites. 2025 Mar 13;15(3):198. doi: 10.3390/metabo15030198.
Cardiovascular diseases are a leading cause of death worldwide, and the process of cardiac remodeling lies at the core of most of these diseases. Sustained cardiac remodeling almost unavoidably ends in progressive muscle dysfunction, heart failure, and ultimately death. Therefore, in order to attenuate cardiac remodeling and reduce mortality, different therapies have been used, but it is important to identify adjuvant factors that can help to modulate this process. One of these factors is the inclusion of affordable foods in the diet with potential cardioprotective properties. Orange juice intake has been associated with several beneficial metabolic changes, which may influence cardiac remodeling induced by cardiovascular diseases. Current opinion highlights how the metabolites and metabolic pathways modulated by orange juice consumption could potentially attenuate cardiac remodeling. It was observed that orange juice intake significantly modulates phospholipids, energy metabolism, endocannabinoid signaling, amino acids, and gut microbiota diversity, improving insulin resistance, dyslipidemia, and metabolic syndrome. Specifically, modulation of phosphatidylethanolamine (PE) metabolism and activation of PPARα and PPARγ receptors, associated with improved energy metabolism, mitochondrial function, and oxidative stress, showed protective effects on the heart. Furthermore, orange juice intake positively impacted gut microbiota diversity and led to an increase in beneficial bacterial populations, correlated with improved metabolic syndrome. These findings suggest that orange juice may act as a metabolic modulator, with potential therapeutic implications for cardiac remodeling associated with cardiovascular diseases.
心血管疾病是全球主要的死亡原因，而心脏重塑过程是大多数此类疾病的核心。持续的心脏重塑几乎不可避免地会导致进行性肌肉功能障碍、心力衰竭，并最终导致死亡。因此，为了减轻心脏重塑并降低死亡率，人们采用了不同的治疗方法，但识别有助于调节这一过程的辅助因素很重要。其中一个因素是在饮食中摄入具有潜在心脏保护特性的平价食物。摄入橙汁与一些有益的代谢变化有关，这些变化可能会影响心血管疾病引起的心脏重塑。目前的观点强调了橙汁消费所调节的代谢物和代谢途径如何有可能减轻心脏重塑。据观察，摄入橙汁可显著调节磷脂、能量代谢、内源性大麻素信号传导、氨基酸和肠道微生物群多样性，改善胰岛素抵抗、血脂异常和代谢综合征。具体而言，磷脂酰乙醇胺（PE）代谢的调节以及PPARα和PPARγ受体的激活，与改善能量代谢、线粒体功能和氧化应激相关，对心脏显示出保护作用。此外，摄入橙汁对肠道微生物群多样性产生了积极影响，并导致有益细菌种群增加，这与改善代谢综合征相关。这些发现表明，橙汁可能作为一种代谢调节剂，对与心血管疾病相关的心脏重塑具有潜在的治疗意义。
