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海狸源菌株对后生元物质——肠菌素的敏感性()。

Susceptibility to Postbiotic Substances-Enterocins of the Strains from Beavers ().

作者信息

Lauková Andrea, Focková Valentína, Maďar Marián, Miltko Renata, Pogány Simonová Monika

机构信息

Centre of Biosciences of the Slovak Academy of Sciences, Institute of Animal Physiology, Šoltésovej 4-6, 040 01 Košice, Slovakia.

Department of Microbiology and Immunology, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, Slovakia.

出版信息

Pathogens. 2025 Mar 11;14(3):269. doi: 10.3390/pathogens14030269.

Abstract

Eurasian beaver () populations have been reintroduced to European countries, though this bears the risk of novel wildlife pathogen reservoir establishment. The species nova was described first in Thailand as a food-derived strain. Later, this species was detected in the feces of pigs, poultry, sewage, and humans. In those studies, the potential risk posed by this species was evaluated. Against that background, the aim of this study was to investigate the susceptibility to postbiotic active substances (enterocins) against fecal strains from beavers caught in Poland. The strains were identified with the use of 16S rRNA gene similarity sequencing. These six strains with low-grade biofilm-forming abilities and two strains with the presence of the virulence factor gene were susceptible to seven enterocins produced by non-autochthonous strains, mostly of the species and . The inhibitory activity against the tested strains reached 25,600 AU/mL. Although the studied strains did not show a strictly pathogenic character, their growth inhibition by postbiotics was identified as a novel elimination strategy.

摘要

欧亚河狸()种群已被重新引入欧洲国家,尽管这存在建立新型野生动物病原体宿主的风险。新物种首先在泰国被描述为一种源自食物的菌株。后来,该物种在猪、家禽的粪便、污水和人类中被检测到。在那些研究中,评估了该物种带来的潜在风险。在此背景下,本研究的目的是调查对后生元活性物质(肠菌素)针对从波兰捕获的河狸粪便中的菌株的敏感性。这些菌株通过16S rRNA基因相似性测序进行鉴定。这六种具有低水平生物膜形成能力的菌株和两种存在毒力因子基因的菌株对非本地菌株产生的七种肠菌素敏感,这些非本地菌株主要是和物种。对测试菌株的抑制活性达到25,600 AU/mL。尽管所研究的菌株未表现出严格的致病特性,但后生元对它们的生长抑制被确定为一种新的消除策略。

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