Carminati Mathilde, Isel Frédéric, Houenou Josselin, Wessa Michèle, Henry Chantal
Département de Psychiatrie et de Médecine Addictologique, Hôpital Lariboisière-Fernand Widal, 75010 Paris, France.
Laboratoire Vision Action Cognition-EA 7326, Institut de Psychologie, Université Paris Cité, 92100 Boulogne-Billancourt, France.
NeuroSci. 2025 Mar 3;6(1):20. doi: 10.3390/neurosci6010020.
People with bipolar disorder (BD) present with mood instability resulting from more frequent and intense emotions in response to environmental conditions relative to healthy subjects. The aim of this study was to investigate the time course of emotion regulation strategies, distraction, and reappraisal in euthymic BD patients (i.e., normal mood range) using electroencephalography (EEG). Fourteen BD patients and 13 matched healthy controls took part in an experiment constituting three conditions, i.e., a passive viewing of positive, negative, and neutral pictures, and two regulation conditions, one with a reappraisal strategy and the other with a distraction strategy. Critically, the ERP results indicated that during passive viewing, the Late Positive Potential (LPP) was larger in BD patients compared with healthy controls, but only for neutral pictures. During emotion regulation, LPP amplitude was reduced in distraction conditions compared with viewing ones, especially for negative emotions in both patients and controls. Importantly, LPP was reduced in reappraisal conditions compared with passive viewing in an early time window for negative emotions and in a later time window for positive emotions in controls but not in patients. Our findings showed that the temporal dynamics of emotion regulation by reappraisal are faster for negative than for positive emotions in controls but not in BD patients.
双相情感障碍（BD）患者相对于健康受试者而言，会因对环境状况产生更频繁、更强烈的情绪反应而出现情绪不稳定。本研究旨在利用脑电图（EEG）研究心境正常的BD患者（即情绪范围正常）情绪调节策略、分心和重新评价的时间进程。14名BD患者和13名匹配的健康对照者参与了一项实验，该实验包含三种条件，即被动观看正性、负性和中性图片，以及两种调节条件，一种采用重新评价策略，另一种采用分心策略。关键的是，ERP结果表明，在被动观看期间，与健康对照者相比，BD患者的晚期正电位（LPP）更大，但仅在观看中性图片时如此。在情绪调节期间，与观看图片时相比，分心条件下的LPP波幅降低，尤其是在患者和对照者面对负性情绪时。重要的是，与被动观看相比，在对照者中，对于负性情绪，在早期时间窗口内重新评价条件下的LPP降低；对于正性情绪，在后期时间窗口内降低，但在BD患者中并非如此。我们的研究结果表明，在对照者中，重新评价对负性情绪的情绪调节时间动态比对正性情绪更快，但在BD患者中并非如此。
