Proskurina M V, Taranushenko T E, Salmin V V, Kiseleva N G
Clinical Hospital No. 51, Federal Medical-Biological Agency of Russia, Zheleznogorsk, Russia.
Bull Exp Biol Med. 2025 Feb;178(4):482-485. doi: 10.1007/s10517-025-06360-8. Epub 2025 Mar 26.
The UV spectra of induced autofluorescence in the skin of children and adolescents with type 1 diabetes mellitus were studied and its relationships with sex, age, duration of diabetes, and chronic complications of the disease were evaluated. The data were presented as a 2D array, the fluorescence spectra were normalized, smoothed by the moving average method with a window of 10 nm, and renormalized taking into account the coefficients found. Significant differences in skin fluorescence spectra were found in children of different ages, with increasing the disease duration and depending on the sex of the patients. When developing non-invasive methods of monitoring the state of carbohydrate metabolism, it is necessary to take into account sex and age, disease duration, and the presence of complications of type 1 diabetes mellitus.
研究了1型糖尿病儿童和青少年皮肤中诱导自发荧光的紫外光谱，并评估了其与性别、年龄、糖尿病病程以及该疾病慢性并发症的关系。数据以二维数组形式呈现，荧光光谱进行了归一化处理，采用窗口为10 nm的移动平均法进行平滑，并根据所发现的系数重新归一化。在不同年龄的儿童中发现了皮肤荧光光谱的显著差异，且随着病程延长以及取决于患者性别。在开发监测碳水化合物代谢状态的非侵入性方法时，有必要考虑1型糖尿病患者的性别、年龄、病程以及并发症的存在情况。
