Yao Shuncheng, Cui Xi, Zhang Chao, Cui Wenguo, Li Zhou
Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China.
Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 101400, China; School of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, 518107, China.
Biomaterials. 2025 Sep;320:123288. doi: 10.1016/j.biomaterials.2025.123288. Epub 2025 Mar 24.
There is a growing recognition that force-electric conversion biomaterials and devices can convert mechanical energy into electrical energy without an external power source, thus potentially revolutionizing the use of electrical stimulation in the biomedical field. Based on this, this review explores the application of force-electric biomaterials and devices in the field of regenerative medicine. The article focuses on piezoelectric biomaterials, piezoelectric devices and triboelectric devices, detailing their categorization, mechanisms of electrical generation and methods of improving electrical output performance. Subsequently, different sources of driving force for electroactive biomaterials and devices are explored. Finally, the biological applications of force-electric biomaterials and devices in regenerative medicine are presented, including tissue regeneration, functional modulation of organisms, and electrical stimulation therapy. The aim of this review is to emphasize the role of electrical stimulation generated by force-electric conversion biomaterials and devices on the regulation of bioactive molecules, ion channels and information transfer in living systems, and thus affects the metabolic processes of organisms. In the future, physiological modulation of electrical stimulation based on force-electric conversion is expected to bring important scientific advances in the field of regenerative medicine.
人们越来越认识到，力电转换生物材料和装置可以在无需外部电源的情况下将机械能转化为电能，从而有可能彻底改变生物医学领域中电刺激的应用。基于此，本综述探讨了力电生物材料和装置在再生医学领域的应用。文章重点介绍了压电生物材料、压电器件和摩擦电器件，详细阐述了它们的分类、发电机制以及提高电输出性能的方法。随后，探讨了电活性生物材料和装置的不同驱动力来源。最后，介绍了力电生物材料和装置在再生医学中的生物学应用，包括组织再生、生物体功能调节和电刺激疗法。本综述的目的是强调力电转换生物材料和装置产生的电刺激对生物活性分子、离子通道和生命系统中信息传递的调节作用，从而影响生物体的代谢过程。未来，基于力电转换的电刺激生理调节有望在再生医学领域带来重要的科学进展。
