TUNEL染色在需要与脂溢性角化病进行病理鉴别诊断的退行性角化棘皮瘤中的诊断效用

Diagnostic Utility of TUNEL Staining for Degenerative Keratoacanthoma Requiring Pathologic Differentiation from Seborrheic Keratosis.

作者信息

Nakanishi Mari, Kondo Makoto, Habe Koji, Hayashi Akinobu, Yamanaka Keiichi

机构信息

Department of Dermatology, Mie University, Graduate School of Medicine, Tsu, Japan.

Department of Oncologic Pathology, Mie University, Graduate School of Medicine, Tsu, Japan.

出版信息

Case Rep Dermatol. 2023 Mar 16;15(1):62-66. doi: 10.1159/000529728. eCollection 2023 Jan-Dec.

DOI:10.1159/000529728

PMID:36936731

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10020938/

Abstract

Tumors developed in 2 old women presented with pathological findings similar to seborrheic keratosis, although the clinical feature of tumor showed typical keratoacanthoma. In addition to these two cases, we compared the pathological findings of a total of four cases, one case each of keratoacanthoma and seborrheic keratosis, which were clinically and histopathological typical. These two cases and the typical keratoacanthoma showed cell apoptosis by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining and infiltration of cytotoxic T cells. The keratoacanthoma in the decompensated stage may be histologically similar to seborrheic keratosis. TUNEL staining can help in the diagnosis of fading keratoacanthoma.

摘要

两名老年女性身上出现的肿瘤，其病理表现类似于脂溢性角化病，尽管肿瘤的临床特征显示为典型的角化棘皮瘤。除这两例病例外，我们还比较了总共四例病例的病理结果，其中角化棘皮瘤和脂溢性角化病各一例，它们在临床和组织病理学上均为典型病例。这两例病例以及典型的角化棘皮瘤通过末端脱氧核苷酸转移酶介导的dUTP缺口末端标记（TUNEL）染色显示细胞凋亡，并伴有细胞毒性T细胞浸润。失代偿期的角化棘皮瘤在组织学上可能与脂溢性角化病相似。TUNEL染色有助于诊断消退期的角化棘皮瘤。