Lee Eun-Ju, Kim Hyoung-Ye, Lee Dong-Woo, Kwon Sai-Won
Department of Public Health, Graduate School, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.
Department of Orthopaedic Surgery, Soonchunhyang University Cheonan Hospital, 31, Suncheonhyang 6-gil, Dongam-gu, Cheonan 31151, Republic of Korea.
Medicina (Kaunas). 2025 Feb 24;61(3):388. doi: 10.3390/medicina61030388.
: This meta-analysis aimed to compare the efficacy of polydioxanone (PDO) suture, a non-surgical treatment for knee osteoarthritis, with intra-articular hyaluronic acid (HA) injections. : A comprehensive literature search was conducted using major databases including MEDLINE, EMBASE, Cochrane Library, KoreaMed, KMBASE, and RISS. Randomized controlled trials (RCTs) published up to 30 April 2024, focusing on knee osteoarthritis, pain, PDO suture, and intra-articular injections, were included. A total of 10 RCTs were analyzed, with participants having Kellgren & Lawrence Grade II-III knee osteoarthritis. This study compared the pain relief effects of PDO suture and HA injections. : The meta-analysis results showed that PDO suture demonstrated consistent and significant pain reduction over a 30-week observation period ( < 0.05), while HA injections did not exhibit statistically significant pain relief. : PDO sutures offer the potential for long-term pain management in patients with knee osteoarthritis. However, this study has limitations such as the heterogeneity among studies, and given that the efficacy of PDO sutures is based on a single study, further research is needed to establish the long-term safety profile of polydioxanone sutures and to ensure the generalizability of the findings.
本荟萃分析旨在比较聚二氧六环酮（PDO）缝线（一种用于膝关节骨关节炎的非手术治疗方法）与关节内注射透明质酸（HA）的疗效。通过使用包括MEDLINE、EMBASE、Cochrane图书馆、KoreaMed、KMBASE和RISS在内的主要数据库进行了全面的文献检索。纳入了截至2024年4月30日发表的、聚焦于膝关节骨关节炎、疼痛、PDO缝线和关节内注射的随机对照试验（RCT）。共分析了10项RCT，参与者为凯尔格伦-劳伦斯分级II-III级的膝关节骨关节炎患者。本研究比较了PDO缝线和HA注射的疼痛缓解效果。荟萃分析结果显示，在30周的观察期内，PDO缝线表现出持续且显著的疼痛减轻（<0.05），而HA注射未显示出具有统计学意义的疼痛缓解。PDO缝线为膝关节骨关节炎患者的长期疼痛管理提供了潜力。然而，本研究存在局限性，如研究之间的异质性，并且鉴于PDO缝线的疗效基于单一研究，需要进一步研究以确立聚二氧六环酮缝线的长期安全性概况，并确保研究结果的可推广性。
