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老年患者的无症状椎体骨折:无论性别发病率均高且普遍存在维生素D缺乏——一项针对身体其他部位发生过骨折患者的初步研究

Silent Vertebral Fractures in Elderly Patients: A High Incidence Regardless of Gender and Widespread Vitamin D Deficiency-A Pilot Study in Patients Who Have Suffered a Fracture Elsewhere in the Body.

作者信息

Schröder Guido, Falk Steffi S I

机构信息

Clinic for Orthopaedics and Trauma Surgery, Sana Hospital Bad Doberan, Academic Teaching Hospital of the University of Rostock, Am Waldrand 1, 18209 Hohenfelde, Germany.

Clinic of Trauma, Hand and Reconstructive Surgery, University of Rostock, Schillingallee 35, 18057 Rostock, Germany.

出版信息

J Clin Med. 2025 Mar 16;14(6):2009. doi: 10.3390/jcm14062009.

DOI:10.3390/jcm14062009
PMID:40142818
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11943146/
Abstract

The present study aims to investigate the influence of systematic radiological screening for silent vertebral fractures (VFs) on osteoporosis diagnosis, treatment decisions, and long-term clinical outcomes compared to standard care without routine screening in elderly patients hospitalised primarily for fractures requiring surgical treatment at sites other than the spine. In a level 1 trauma centre, patients with fractures requiring surgical treatment after low-energy trauma were prospectively examined over a period of 12 months. Using radiographs of the thoracic and lumbar spine in two planes, previously unknown VFs were identified and categorised according to the classification for osteoporotic fractures (OFs) of the thoracolumbar spine. A total of 106 patients with a mean age of 79.4 years participated in this study, and 112 previously unknown vertebral compression fractures were diagnosed in 57% (60/106) of the patients. In this group, lumbar vertebra 2 was the most frequently affected, and the majority of these VFs were classified as OF 2, which corresponds to an isolated endplate fracture with minimal involvement of the posterior wall. Furthermore, 26% (28/106) of the patients in the evaluation showed VFs at multiple levels. This study revealed no statistically significant difference in the prevalence of silent VFs between male and female patients ( = 0.055). Additionally, the analysis revealed that nearly 75% of patients exhibited vitamin D insufficiency. The high prevalence of silent VFs in elderly patients emphasises the necessity for systematic radiological investigations, irrespective of gender.

摘要

本研究旨在调查与未进行常规筛查的标准护理相比,对无症状椎体骨折(VF)进行系统放射学筛查对骨质疏松症诊断、治疗决策和长期临床结局的影响,研究对象为主要因非脊柱部位骨折需要手术治疗而住院的老年患者。在一家一级创伤中心,对低能量创伤后需要手术治疗的骨折患者进行了为期12个月的前瞻性检查。使用胸腰椎两个平面的X线片,识别先前未知的VF,并根据胸腰椎骨质疏松性骨折(OF)的分类进行分类。共有106例平均年龄为79.4岁的患者参与了本研究,57%(60/106)的患者诊断出112处先前未知的椎体压缩骨折。在该组中,第2腰椎是最常受累的部位,这些VF大多数被分类为OF 2,相当于孤立的终板骨折,后壁受累最小。此外,评估中有26%(28/106)的患者在多个节段出现VF。本研究显示,男性和女性患者无症状VF的患病率无统计学显著差异(P = 0.055)。此外,分析显示近75%的患者存在维生素D不足。老年患者无症状VF的高患病率强调了无论性别,进行系统放射学检查的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510e/11943146/d8968f797e0a/jcm-14-02009-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510e/11943146/40635d0173eb/jcm-14-02009-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510e/11943146/516ce0362fdc/jcm-14-02009-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510e/11943146/d8968f797e0a/jcm-14-02009-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510e/11943146/40635d0173eb/jcm-14-02009-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510e/11943146/516ce0362fdc/jcm-14-02009-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/510e/11943146/d8968f797e0a/jcm-14-02009-g003.jpg

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Nutrients. 2024 Nov 30;16(23):4174. doi: 10.3390/nu16234174.
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Prevalence, incidence of and risk factors for vertebral fracture in the community: the Vietnam Osteoporosis Study.社区中椎体骨折的患病率、发生率和危险因素:越南骨质疏松研究。
Sci Rep. 2024 Jan 2;14(1):32. doi: 10.1038/s41598-023-50145-w.
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Cost-effectiveness of opportunistic QCT-based osteoporosis screening for the prediction of incident vertebral fractures.
基于机会性 QCT 的骨质疏松症筛查对预测新发椎体骨折的成本效益。
Front Endocrinol (Lausanne). 2023 Jul 31;14:1222041. doi: 10.3389/fendo.2023.1222041. eCollection 2023.
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Cost Effectiveness Analyses of Interventions for Osteoporosis in Men: A Systematic Literature Review.男性骨质疏松症干预措施的成本效果分析:系统文献回顾。
Pharmacoeconomics. 2023 Apr;41(4):363-391. doi: 10.1007/s40273-022-01239-2. Epub 2023 Feb 4.
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Discrepancies Between Osteoporotic Fracture Evaluations in Men Based on German (DVO) Osteoporosis Guidelines or the FRAX Score.男性骨质疏松性骨折评估的德国骨质疏松症指南(DVO)或 FRAX 评分之间的差异。
Exp Clin Endocrinol Diabetes. 2023 Mar;131(3):114-122. doi: 10.1055/a-1977-4413. Epub 2022 Nov 11.
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