Mader J T
Am J Med. 1985 Jun 28;78(6B):213-7. doi: 10.1016/0002-9343(85)90387-0.
Clinical research involving osteomyelitis is difficult because of the multiple variables found in the disease process. In order to evaluate osteomyelitis critically, a more precise staging system is needed, along with reproducible animal models for each of the clinical stages. The current animal models for osteomyelitis include the rabbit models of Norden and Andriole, the rat model of Zak, and the dog models of Fitzgerald and Deysine. Although each animal model of osteomyelitis has certain advantages and limitations, they have provided us with a clearer understanding of this disease process and what forms of treatment may prove satisfactory.
由于在疾病过程中存在多种变量，涉及骨髓炎的临床研究颇具难度。为了严谨地评估骨髓炎，需要一个更精确的分期系统，以及适用于每个临床阶段的可重复的动物模型。目前用于骨髓炎的动物模型包括诺登（Norden）和安德里奥尔（Andriole）的兔模型、扎克（Zak）的大鼠模型以及菲茨杰拉德（Fitzgerald）和戴辛（Deysine）的犬模型。尽管每种骨髓炎动物模型都有一定的优点和局限性，但它们让我们对这种疾病过程以及哪些治疗形式可能令人满意有了更清晰的认识。
