Dillon L, Glenn F, Becker C G
Am J Pathol. 1982 Dec;109(3):253-8.
In previous studies in this laboratory it was demonstrated that 1) constituents of the water-soluble phase of cigarette smoke condensate can activate Hageman-factor-dependent pathways of coagulation, fibrinolysis, and kinin generation; and 2) that in vivo activation of Hageman-factor-dependent pathways by intravenous injection of plant polyphenols in dogs and AFrican Green monkeys can induce acute acalculous cholecystitis and alveolitis. The purpose of this communication is to report that inhalation of the water-soluble, nondialyzable constituents of cigarette smoke condensate, or "tar," can activate Hageman-factor-dependent pathways in the dog and induce acute acalculous cholecystitis, pneumonitis, and the formation of thrombi in branches of pulmonary vessels.
1）香烟烟雾冷凝物水溶性成分可激活依赖于Hageman因子的凝血、纤维蛋白溶解和激肽生成途径；2）在狗和非洲绿猴体内静脉注射植物多酚激活依赖于Hageman因子的途径可诱发急性非结石性胆囊炎和肺泡炎。本通讯的目的是报告吸入香烟烟雾冷凝物的水溶性、不可透析成分即“焦油”，可激活狗体内依赖于Hageman因子的途径，并诱发急性非结石性胆囊炎、肺炎以及肺血管分支内血栓形成。
