Mogi G, Kawauchi H, Suzuki M, Sato N
Am J Otolaryngol. 1985 May-Jun;6(3):142-7. doi: 10.1016/s0196-0709(85)80076-4.
Previously the authors proposed that the perilymphatic inner ear immune system is independent of that of the cerebrospinal fluid. In the present study, the effect of dilatation of blood vessels surrounding the cochlea of chinchillas on the transfer of serum antibodies to the perilymph was tested. The possibility of local production of antibodies in the perilymphatic space was also investigated by antigen introduction into the inner ear through the facial nerve canal. The dilatation of blood vessels accelerated the transfer of serum antibodies to the perilymph, even though this transfer activity was limited. Results of the study, showing the effect of antibody production in the perilymphatic space upon introduction of antigen into the inner ear through the facial nerve canal, would deny local antibody production in the inner ear, particularly in the perilymphatic space.
此前，作者们提出内耳外淋巴免疫系统独立于脑脊液免疫系统。在本研究中，测试了龙猫耳蜗周围血管扩张对血清抗体向外淋巴转移的影响。还通过经面神经管向内耳引入抗原，研究了外淋巴间隙中抗体局部产生的可能性。血管扩张加速了血清抗体向外淋巴的转移，尽管这种转移活性有限。本研究结果显示经面神经管向内耳引入抗原后外淋巴间隙中抗体产生的情况，将否定内耳特别是外淋巴间隙中抗体的局部产生。
