用于检测被忽视传染病的等离子体超表面的先进计算技术

Advanced Computational Techniques for Plasmonic Metasurfaces in the Detection of Neglected Infectious Diseases.

作者信息

Teixeira Felipe M F, Portes Ary V R, Marques Talles E M, H Isayama Yuri, de Freitas Felipe A N, Santana Fabiano C, Mendes da Rocha Aline, Moraes Thais F S, Andrade Lidia M, Versiani Alice F, Martins Estefânia M N, Cotta Eduardo A, Rodrigues Wagner N, Nagem Ronaldo A P, da Fonseca Flávio G, Furtado Clascidia A, C Ramirez Jhonattan

机构信息

Departamento de Engenharia Eletrônica, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.

Programa de Pós-Graduação em Engenharia Elétrica, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.

出版信息

Anal Chem. 2025 Apr 8;97(13):6813-6825. doi: 10.1021/acs.analchem.4c04934. Epub 2025 Mar 27.

DOI:10.1021/acs.analchem.4c04934

PMID:40146682

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11983362/

Abstract

This tutorial delves into the integration of plasmonic metasurfaces as cutting-edge tools for creating highly sensitive diagnostic assays tailored to neglected infectious diseases. Plasmonic metasurfaces provide a transformative approach to diagnostics by addressing common limitations of traditional methods, including slow results and high costs. This tutorial explores their application in advancing sensitive and cost-effective solutions for neglected infectious diseases. This manuscript covers the complete cycle of developing optimized, AI-driven plasmonic metasurfaces, from biofunctionalization strategies and advanced fabrication techniques to addressing scalability, regulatory challenges, and point-of-care accessibility in resource-limited settings.

摘要

本教程深入探讨了等离激元超表面作为前沿工具的整合，用于创建针对被忽视的传染病的高灵敏度诊断检测方法。等离激元超表面通过解决传统方法的常见局限性，包括结果缓慢和成本高昂，为诊断提供了一种变革性方法。本教程探讨了它们在推进针对被忽视的传染病的灵敏且经济高效的解决方案方面的应用。本手稿涵盖了开发优化的、人工智能驱动的等离激元超表面的完整周期，从生物功能化策略和先进制造技术到解决资源有限环境中的可扩展性、监管挑战和即时检测可及性。