Metal-organic framework-based nanozymes for water-soluble antioxidants and Total antioxidant capacity detection: Principles and applications.

Nanozymes, engineered catalysts exhibiting catalytic properties, have emerged as key players at the interface of nanotechnology and biology, holding great promise in diverse food applications. Notably, nanoscale metal-organic frameworks (MOFs) have gained widespread recognition as flexible platforms for developing potent nanozymes. This review explores the design, development, and applications of MOF-based nanozymes, with a focus on their potential in detecting antioxidants and total antioxidant capacity (TAC), two critical parameters in the assessment of oxidative stress and related diseases. A comprehensive classification of these MOF-based nanozymes is presented, based on their catalytic activities, and recent advancements in their application to antioxidants and TAC detection are discussed. The review further delves into the challenges faced by MOF nanozymes in these areas, including issues related to stability, reproducibility, and selectivity. By addressing these challenges and proposing potential solutions, the review offers future perspectives on advancing the use of MOF nanozymes in sensing applications.