Ameen Sameera Sh Mohammed, Omer Khalid M
Department of Chemistry, College of Science, University of Zakho, 42002, Zakho, Kurdistan region, Iraq.
Department of Chemistry, College of Science, University of Sulaimani, Qliasan St. 46002, Sulaymaniyah, Kurdistan region, Iraq.
Food Chem. 2025 Jul 1;479:143876. doi: 10.1016/j.foodchem.2025.143876. Epub 2025 Mar 14.
Nanozymes, engineered catalysts exhibiting catalytic properties, have emerged as key players at the interface of nanotechnology and biology, holding great promise in diverse food applications. Notably, nanoscale metal-organic frameworks (MOFs) have gained widespread recognition as flexible platforms for developing potent nanozymes. This review explores the design, development, and applications of MOF-based nanozymes, with a focus on their potential in detecting antioxidants and total antioxidant capacity (TAC), two critical parameters in the assessment of oxidative stress and related diseases. A comprehensive classification of these MOF-based nanozymes is presented, based on their catalytic activities, and recent advancements in their application to antioxidants and TAC detection are discussed. The review further delves into the challenges faced by MOF nanozymes in these areas, including issues related to stability, reproducibility, and selectivity. By addressing these challenges and proposing potential solutions, the review offers future perspectives on advancing the use of MOF nanozymes in sensing applications.
纳米酶是具有催化特性的工程催化剂，已成为纳米技术与生物学交叉领域的关键角色，在各种食品应用中具有巨大潜力。值得注意的是，纳米级金属有机框架（MOF）作为开发高效纳米酶的灵活平台已获得广泛认可。本综述探讨了基于MOF的纳米酶的设计、开发和应用，重点关注其在检测抗氧化剂和总抗氧化能力（TAC）方面的潜力，这是评估氧化应激和相关疾病的两个关键参数。基于其催化活性，对这些基于MOF的纳米酶进行了全面分类，并讨论了它们在抗氧化剂和TAC检测应用中的最新进展。该综述进一步深入探讨了MOF纳米酶在这些领域面临的挑战，包括与稳定性、可重复性和选择性相关的问题。通过应对这些挑战并提出潜在解决方案，该综述为推进MOF纳米酶在传感应用中的使用提供了未来展望。
