Shafran S D, Wong J, Chow A W
Antimicrob Agents Chemother. 1985 May;27(5):749-52. doi: 10.1128/AAC.27.5.749.
The in vitro activities of Sch 34343, a new penem antibiotic, and cefbuperazone, a new cephamycin antibiotic, were determined against 459 clinical anaerobic bacterial isolates and compared with the activities of imipenem and cefoxitin, respectively, by an agar dilution method. Both penems showed potent and similar activity against all anaerobic bacteria tested, particularly Peptococcus spp., Bacteroides fragilis, and Clostridium perfringens. All organisms except a single strain of Fusobacterium necrogenes were inhibited by an 8 micrograms/ml concentration of either Sch 34343 or imipenem. Overall, gram-positive bacilli, particularly Lactobacillus species, Clostridium difficile, and Bifidobacterium and Actinomyces species, were relatively more resistant to either penem than other genera of anaerobic bacteria tested. Cefbuperazone demonstrated only modest activity against a wide spectrum of anaerobic bacteria. It had excellent and selective activity against B. fragilis and Bacteroides vulgatus but was highly inactive against Bacteroides distasonis and Bacteroides thetaiotaomicron within the B. fragilis group. Both cephamycins showed virtually no activity against C. difficile and Lactobacillus spp. Although cefbuperazone was more active against Bifidobacterium spp., it had less activity against Fusobacterium spp., Eubacterium spp., and all Bacteroides spp. other than B. fragilis and B. vulgatus.
采用琼脂稀释法测定了新型青霉烯类抗生素Sch 34343和新型头孢霉素类抗生素头孢哌酮对459株临床分离厌氧菌的体外活性，并分别与亚胺培南和头孢西丁的活性进行了比较。两种青霉烯类抗生素对所有测试的厌氧菌均显示出强效且相似的活性，尤其是消化球菌属、脆弱拟杆菌和产气荚膜梭菌。除1株坏死梭杆菌外，所有菌株在Sch 34343或亚胺培南浓度为8微克/毫升时均受到抑制。总体而言，革兰氏阳性杆菌，尤其是乳杆菌属、艰难梭菌、双歧杆菌属和放线菌属，相对于其他测试的厌氧菌类，对这两种青霉烯类抗生素的耐药性相对较高。头孢哌酮对多种厌氧菌仅表现出适度的活性。它对脆弱拟杆菌和普通拟杆菌具有优异的选择性活性，但对脆弱拟杆菌组中的解脲拟杆菌和多形拟杆菌高度无活性。两种头孢霉素对艰难梭菌和乳杆菌属几乎均无活性。虽然头孢哌酮对双歧杆菌属的活性更强，但对梭杆菌属、真杆菌属以及除脆弱拟杆菌和普通拟杆菌外的所有拟杆菌属的活性较低。
