Kesado T, Watanabe K, Asahi Y, Isono M, Ueno K
Antimicrob Agents Chemother. 1982 Jun;21(6):1016-22. doi: 10.1128/AAC.21.6.1016.
The susceptibilities of 462 clinical anaerobic bacterial isolates to N-formimidoyl thienamycin and 16 other currently available and investigational antibiotics were determined by the agar dilution technique. N-Formimidoyl thienamycin was significantly more active than the reference antibiotics against most organisms tested, especially Bacteroides sp., including clindamycin-resistant strains. All 462 isolates were inhibited by 4 micrograms of N-formimidoyl thienamycin per ml, and no resistant strains were found in the species tested. N-Formimidoyl thienamycin was less active (i.e., had a higher 50% minimal inhibitory concentration) against Fusobacterium sp. than clindamycin, SM-1652, and piperacillin, and less active against Clostridium difficile than metronidazole, but was equally active or more active than the other reference antibiotics tested.
采用琼脂稀释法测定了462株临床分离厌氧菌对N-甲酰亚胺硫霉素及其他16种现有和正在研究的抗生素的敏感性。N-甲酰亚胺硫霉素对大多数测试菌的活性显著高于参考抗生素，尤其是对拟杆菌属，包括对克林霉素耐药的菌株。所有462株分离菌均被每毫升4微克的N-甲酰亚胺硫霉素抑制，在所测试的菌种中未发现耐药菌株。N-甲酰亚胺硫霉素对梭杆菌属的活性低于克林霉素、SM-1652和哌拉西林（即50%最小抑菌浓度较高），对艰难梭菌的活性低于甲硝唑，但与其他测试参考抗生素活性相当或更高。
