Savilahti E, Simell O
Arch Dis Child. 1985 May;60(5):452-6. doi: 10.1136/adc.60.5.452.
Recurrent, unexplained diarrhoea is the most common intestinal complaint in children aged 6 months to 3 years. We studied 27 consecutive children with this complaint and followed them up until the age of 5 years. Diarrhoea began at the mean age of 9 months (range 4 to 16 months) and resolved in 21 children by 3 years of age. Twelve children had had infantile colic earlier. In six patients diarrhoea was caused by food allergy (cows' milk allergy and allergy to fresh vegetables). Episodes of diarrhoea persisted in four of these six. Twenty one children had unexplained diarrhoea: this resolved in 19. Nutritional deficiencies were rare; only one child had iron deficiency. Relative weights of the children were significantly lower at 2 years than at 1 year of age. At 5 years of age six of the children continued to have episodes of diarrhoea, and abdominal pains, headaches, and atopy occurred more commonly than in the general population. We suggest that there are two major subgroups among children with recurrent diarrhoea--children with food allergy and those who react to environmental stresses with a variety of somatic symptoms.
反复出现的不明原因腹泻是6个月至3岁儿童最常见的肠道问题。我们对27名有此问题的儿童进行了连续研究，并对他们进行随访直至5岁。腹泻开始的平均年龄为9个月（范围4至16个月），21名儿童在3岁时腹泻症状消失。12名儿童此前曾患婴儿腹绞痛。6名患者的腹泻由食物过敏（牛奶过敏和对新鲜蔬菜过敏）引起。这6名患者中有4名腹泻症状持续存在。21名儿童患有不明原因腹泻：其中19名症状消失。营养缺乏情况很少见；只有1名儿童缺铁。这些儿童在2岁时的相对体重明显低于1岁时。5岁时，6名儿童仍有腹泻发作，而且腹痛、头痛和特应性疾病的发生比普通人群更为常见。我们认为，反复腹泻的儿童主要分为两个亚组——食物过敏儿童和对环境压力产生各种躯体症状反应的儿童。
