Zheng Tiantian, Meng Chenchen, Lv Zhengtian, Wu Chenxia, Zhou Xinbin, Mao Wei
The First School of Clinical Medicine, Zhejiang Chinese Medical University, 310053 Hangzhou, Zhejiang, China.
Department of Cardiology, Affiliated Zhejiang Hospital, Zhejiang University School of Medicine, 310030 Hangzhou, Zhejiang, China.
Rev Cardiovasc Med. 2025 Mar 20;26(3):26740. doi: 10.31083/RCM26740. eCollection 2025 Mar.
Due to the continued aging of the global population, cardiovascular diseases (CVDs) remain the main cause of death worldwide, with millions of fatalities from diseases, including stroke and coronary artery disease, reported annually. Thus, novel therapeutic approaches and targets are urgently required for diagnosing and treating CVDs. Recent studies emphasize the vital part of gut microbiota in both CVD prevention and management. Among these, () has emerged as a promising probiotic capable of improving intestinal health. Although preliminary investigations demonstrate that positively enhances cardiovascular health, research specifically connecting this strain to CVD outcomes remains limited. Based on current research and assessment of possible clinical applications, this paper aimed to investigate the positive effects on cardiovascular health using and its metabolites. Targeting gut flora is expected to become a mainstay in CVD treatment as research develops.
由于全球人口持续老龄化,心血管疾病(CVDs)仍然是全球主要的死亡原因,每年有数百万人死于包括中风和冠状动脉疾病在内的疾病。因此,迫切需要新的治疗方法和靶点来诊断和治疗心血管疾病。最近的研究强调了肠道微生物群在心血管疾病预防和管理中的重要作用。其中,()已成为一种有前途的益生菌,能够改善肠道健康。尽管初步研究表明()能积极改善心血管健康,但将该菌株与心血管疾病结果具体联系起来的研究仍然有限。基于目前的研究和对可能临床应用的评估,本文旨在研究()及其代谢产物对心血管健康的积极影响。随着研究的发展,针对肠道菌群有望成为心血管疾病治疗的主要手段。