Univ. Lille, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (Inserm), Centre Hospitalier Universitaire (CHU) Lille, Institut Pasteur de Lille, U1019-Unité Mixte de Recherche (UMR) 9017 - CIIL - Centre d'Infection et d'Immunité de Lille, Lille, France.
Biomnigene Société Anonyme (SA), Besançon, France.
Front Immunol. 2024 Mar 12;15:1347676. doi: 10.3389/fimmu.2024.1347676. eCollection 2024.
The gut-lung axis is critical during viral respiratory infections such as influenza. Gut dysbiosis during infection translates into a massive drop of microbially produced short-chain fatty acids (SCFAs). Among them, butyrate is important during influenza suggesting that microbiome-based therapeutics targeting butyrate might hold promises. The butyrate-producing bacterium (formerly referred to as ) is an emerging probiotic with several health-promoting characteristics. To investigate the potential effects of on influenza outcomes, mice were gavaged with live (A2-165 or I-4574 strains) five days before infection. Supplementation of was associated with less severe disease, a lower pulmonary viral load, and lower levels of lung inflammation. supplementation impacted on gut dysbiosis induced by infection, as assessed by 16S rRNA sequencing. Interestingly, administration was associated with a recovery in levels of SCFAs (including butyrate) in infected animals. The live form of more potent that the pasteurized form in improving influenza outcomes. Lastly, partially protected against secondary (systemic) bacterial infection. We conclude that might serve as a novel next generation probiotic against acute viral respiratory diseases.
肠-肺轴在流感等病毒性呼吸道感染中至关重要。感染期间肠道菌群失调会导致微生物产生的短链脂肪酸（SCFAs）大量减少。其中，丁酸盐在流感期间很重要，这表明针对丁酸盐的基于微生物组的治疗方法可能有希望。产丁酸盐细菌（以前称为 ）是一种新兴的益生菌，具有多种促进健康的特性。为了研究 对流感结果的潜在影响，在感染前五天用活 （A2-165 或 I-4574 株）灌胃小鼠。补充 与疾病严重程度降低、肺部病毒载量降低和肺部炎症水平降低有关。补充 会影响感染引起的肠道菌群失调，这可以通过 16S rRNA 测序来评估。有趣的是， 给药与感染动物中 SCFAs（包括丁酸盐）水平的恢复有关。活菌形式的 比巴氏杀菌形式更能改善流感结果。最后， 部分保护免受继发性（全身）细菌感染。我们得出结论， 可能成为针对急性病毒性呼吸道疾病的新型下一代益生菌。
