Harris Rebecca Arden, Khatana Sameed Ahmed M, Long Judith A
Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.
Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, PA, USA.
Prev Med Rep. 2025 Feb 6;51:102997. doi: 10.1016/j.pmedr.2025.102997. eCollection 2025 Mar.
This study aimed to estimate and compare cardiometabolic disease (CMD) mortality in U.S. Black and White men during the transition from early adulthood to middle age.
Using 2022 National Vital Statistics System data and standard period life table methods, we estimated the risk of CMD death in hypothetical cohorts of Black and White men from age 25 to 45 years. We estimated cumulative risk, excess mortality, years of lost life (YLL), and proportion of deaths due to CMD, stratifying by metabolic and cardiovascular disease.
Of the 325,134 Black men aged 25 years in the initial cohort, the cumulative risk of cardiometabolic death before age 45 was one in 63 individuals or 1.58 %. For White men, the risks were markedly lower. Of the 1,185,384 White men aged 25 years in the initial cohort, the cumulative risk of cardiometabolic death before age 45 was one in 158 individuals or 0.63 %. The study also found that of the 5141 expected CMD deaths in the Black cohort, 3090 or 60.10 % were excess deaths relative to the White cohort. Additionally, the proportion of all deaths due to CMD among Black men was 19.15 % rising from 6.02 % at age 25 to 38.00 % at age 45, compared with 11.10 % among White men, increasing from 4.57 % at age 25 to 19.79 % at age 45. The YLL for Black men averaged 6.72 months per person while White men averaged 2.94 months.
This investigation shows profound racial disparities in CMD mortality from early to mid-adulthood.
本研究旨在估计并比较美国黑人和白人男性从青年期到中年期过渡阶段中心血管代谢疾病（CMD）的死亡率。
利用2022年国家生命统计系统数据和标准时期生命表方法，我们估计了25至45岁的黑人和白人男性假设队列中CMD死亡风险。我们估计了累积风险、超额死亡率、生命损失年数（YLL）以及CMD导致的死亡比例，并按代谢和心血管疾病进行分层。
在初始队列中，325,134名25岁的黑人男性中，45岁前心血管代谢死亡的累积风险为63人中1人，即1.58%。对于白人男性，风险显著更低。在初始队列中，1,185,384名25岁的白人男性中，45岁前心血管代谢死亡的累积风险为158人中1人，即0.63%。该研究还发现，在黑人队列预期的5141例CMD死亡中，相对于白人队列，有3090例或60.10%为超额死亡。此外，黑人男性中因CMD导致的所有死亡比例为19.15%，从25岁时的6.02%上升至45岁时的38.00%，而白人男性中这一比例为11.10%，从25岁时的4.57%上升至45岁时的19.79%。黑人男性的YLL平均每人6.72个月，而白人男性平均为2.94个月。
本调查显示了从青年期到中年期CMD死亡率方面存在深刻的种族差异。
