Matton P, Maurasse C
Biol Reprod. 1985 Jun;32(5):1095-100. doi: 10.1095/biolreprod32.5.1095.
Deciduomal response was studied in female rats androgenized with a single injection of 1 mg of testosterone propionate at 5 days of age. Endometrial scratching in immature rats (33 days) elicited a better response in androgenized rats (AF) than in controls (NF) following induction of ovulation or steroid replacement therapy. In adult females receiving cervical stimulation at estrus or induction of ovulation, strong deciduomal response was obtained in NF rats and no response was observed in AF rats. In ovariectomized (OVX) rats receiving 2 mg of progesterone (P), the response in AF was only 50% that of NF rats. Addition of 0.1 mg of estradiol (E2) enhanced the decidualization in NF rats but completely abolished that of AF rats. Following ovariectomy and a period of 12-15 days without any exogenous hormone, an E2 priming treatment (0.2 or 0.5 micrograms) for 3 days followed by a replacement therapy (2.0 mg P + 0.1 or 0.15 micrograms E2) allowed good response in NF rats. The response was reduced by 30-35% in AF rats receiving 0.1 micrograms of E2 during the replacement therapy and by 66% in AF rats receiving 0.15 micrograms of E2. These results indicate that in AF rats the reduction of the response is age dependent, the uterus is more sensitive to E2 than is the uterus of NF rats and the growth response is always submaximal.
对出生5天时单次注射1毫克丙酸睾酮进行雄激素化处理的雌性大鼠的蜕膜反应进行了研究。在未成熟大鼠（33天龄）中进行子宫内膜刮擦，在诱导排卵或类固醇替代疗法后，雄激素化大鼠（AF）的反应比对照组（NF）更好。在发情期接受宫颈刺激或诱导排卵的成年雌性大鼠中，NF大鼠获得了强烈的蜕膜反应，而AF大鼠未观察到反应。在接受2毫克孕酮（P）的去卵巢（OVX）大鼠中，AF组的反应仅为NF组的50%。添加0.1毫克雌二醇（E2）可增强NF大鼠的蜕膜化，但完全消除了AF大鼠的蜕膜化。去卵巢并经过12 - 15天无任何外源激素处理后，进行为期3天的E2预处理（0.2或0.5微克），然后进行替代疗法（2.0毫克P + 0.1或0.15微克E2），NF大鼠有良好反应。在替代疗法期间接受0.1微克E2的AF大鼠中，反应降低了30 - 35%，在接受0.15微克E2的AF大鼠中，反应降低了66%。这些结果表明，在AF大鼠中，反应的降低与年龄有关，子宫对E2的敏感性高于NF大鼠的子宫，且生长反应总是低于最大值。
