Wu Zeyu, Liu Jiang, Fang Qifan, Yang Ying, Fan Yiyue
Department of Pain Management, Shunqing District, Beijing Anzhen Nanchong Hospital, Capital Medical University & Nanchong Central Hospital, Sichuan Province, No.97, South Renmin Road, Nanchong City, 637000, China.
Neurosurg Rev. 2025 Mar 31;48(1):341. doi: 10.1007/s10143-025-03490-5.
To systematically evaluate the efficacy and recurrence rate of radiofrequency treatment for Glossopharyngeal Neuralgia, providing evidence-based support for clinical treatment. Systematic searches were conducted in databases including CNKI, Wanfang Data, VIP, PubMed, EMbase, and Cochrane Library from inception to September 30, 2024, for both Chinese and English literature on radiofrequency treatment of Glossopharyngeal neuralgia. Literature was strictly screened according to inclusion and exclusion criteria and data were processed and analyzed using RevMan 5.4 software for Meta-analysis. A total of 13 studies involving 437 patients were ultimately included. Meta-analysis results showed that Radiofrequency treatment resulted in significant improvements in pain scores at all postoperative time points (SMD = 3.38 at immediate postoperative, SMD = 4.18 at 1 month,SMD = 3.44 at 3 month,SMD = 2.94 at 6 month, SMD = 2.96 at 12 month) compared to baseline.The efficacy rate within one week after radiofrequency treatment was 84%. The efficacy rate within one year after radiofrequency treatment was 80%. The recurrence rate within one year after radiofrequency treatment was 13%. The incidence of complications within one year after radiofrequency treatment was 29%. Sensitivity analysis results indicated that the findings of this study are robust. Publication bias analysis showed that there is a low likelihood of publication bias in this study. Radiofrequency treatment for glossopharyngeal neuralgia has a good efficacy rate and a low recurrence rate, with radiofrequency thermocoagulation combined with Nerve destroying drugs showing the highest efficacy rate and the lowest recurrence rate, but there are certain complications.
为系统评价射频治疗舌咽神经痛的疗效及复发率，为临床治疗提供循证支持。检索中国知网、万方数据、维普、PubMed、EMbase和Cochrane图书馆等数据库，收集自建库至2024年9月30日有关射频治疗舌咽神经痛的中英文文献。严格按照纳入与排除标准筛选文献，采用RevMan 5.4软件进行数据处理与分析以进行Meta分析。最终纳入13项研究，共437例患者。Meta分析结果显示，与基线相比，射频治疗在术后各时间点的疼痛评分均有显著改善（术后即刻SMD = 3.38，1个月时SMD = 4.18，3个月时SMD = 3.44，6个月时SMD = 2.94，12个月时SMD = 2.96）。射频治疗后1周内有效率为84%。射频治疗后1年内有效率为80%。射频治疗后1年内复发率为13%。射频治疗后1年内并发症发生率为29%。敏感性分析结果表明本研究结果可靠。发表偏倚分析显示本研究存在发表偏倚的可能性较低。射频治疗舌咽神经痛有效率高、复发率低，其中射频热凝联合神经毁损药物有效率最高、复发率最低，但存在一定并发症。
