Schellack Sophie Klara, Breidenbach Clara, Kowalski Christoph, Wedding Ulrich, van Oorschot Birgitt, Seufferlein Thomas, Benz Stefan, Schnell Martin, Köninger Jörg, Klein Christina, Ockenga Johann, Freitag Björn, Wittel Uwe A, Wahba Roger, Kim Mia, Elhabash Saleem, Piso Pompiliu, Weyhe Dirk, Bunse Jörg, Riechmann Maren, von Strauss Marco, Petzoldt Sebastian, Neumann Philipp-Alexander, Kolb Vanessa, Sibert Nora Tabea
German Cancer Society, Kuno-Fischer-Straße 8, 14057, Berlin, Germany.
University Medicine Jena, Kastanienstraße 1, 07747, Jena, Germany.
J Cancer Res Clin Oncol. 2025 Mar 31;151(4):127. doi: 10.1007/s00432-025-06186-x.
Diagnosis with UICC stage IV colorectal cancer often indicates palliative treatment to alleviate symptoms. Data on pain in these patients are still scarce but can help improve symptom management. This study therefore aimed to describe patient-reported pain and quality of life.
147 palliatively treated stage IV colorectal cancer patients diagnosed between 2018 and 2023 completed the EORTC QLQ-C30 and QLQ-CR29 before and 12 months after treatment initiation within the EDIUM study. Descriptive results for pain and quality of life were examined and compared to reference values. A logistic regression analysis investigated the relationship between quality of life and pain and 1-year survival.
The mean (SD) for the "overall pain" score was 26 (32) (T0) and 35 (32) (T1) for rectal cancer patients and 34 (33) (T0) and 35 (32) (T1) for colon cancer patients. This is higher than the reference value (24 (30)) and indicates high average pain levels. The "overall quality of life" score showed means below the reference value (61 (23)), indicating poorer quality of life (colon: 51 (25) (T0), 56 (22) (T1); rectum: 52 (24) (T0), 51 (22) (T1)). Higher pain levels persisted at both time points, with no patients reporting absence of pain. The logistic regression results suggest a small relationship between pain and quality of life and 1-year survival.
This study reveals high levels of pain among palliatively treated colorectal cancer patients, impacting their quality of life. Effective pain management and close monitoring are necessary to improve the quality of life for these patients.
DRKS00008724.
国际抗癌联盟（UICC）IV期结直肠癌的诊断通常意味着采取姑息治疗以缓解症状。关于这些患者疼痛情况的数据仍然稀少，但有助于改善症状管理。因此，本研究旨在描述患者报告的疼痛及生活质量。
在EDIUM研究中，147例于2018年至2023年间确诊并接受姑息治疗的IV期结直肠癌患者在治疗开始前及开始后12个月完成了欧洲癌症研究与治疗组织（EORTC）QLQ-C30和QLQ-CR29问卷。对疼痛和生活质量的描述性结果进行了检查，并与参考值进行比较。逻辑回归分析研究了生活质量与疼痛及1年生存率之间的关系。
直肠癌患者“总体疼痛”评分的平均值（标准差）在T0时为26（32），在T1时为35（32）；结肠癌患者在T0时为34（33），在T1时为35（32）。这高于参考值（24（30）），表明平均疼痛水平较高。“总体生活质量”评分显示平均值低于参考值（61（23）），表明生活质量较差（结肠癌：T0时为51（25），T1时为56（22）；直肠癌：T0时为52（24），T1时为51（22））。两个时间点的疼痛水平均持续较高，没有患者报告无疼痛。逻辑回归结果表明疼痛与生活质量及1年生存率之间存在微弱关系。
本研究揭示了接受姑息治疗的结直肠癌患者疼痛程度较高，影响了他们的生活质量。有效的疼痛管理和密切监测对于改善这些患者的生活质量是必要的。试验编号：DRKS00008724。
