晚期结直肠癌患者的健康相关生活质量：系统评价和荟萃分析。
Health-related quality of life in patients with colorectal cancer in the palliative phase: a systematic review and meta-analysis.
机构信息
Department of Nursing and Health Promotion. Faculty of Health Sciences, OsloMet - Oslo Metropolitan University, P.O. Box 4, St. Olavs plass, NO-0130, Oslo, Norway.
Department of Bachelor in Nursing, Lovisenberg Diaconal University College, Lovisenberggata 15B, NO-0456, Oslo, Norway.
出版信息
BMC Palliat Care. 2021 Sep 16;20(1):144. doi: 10.1186/s12904-021-00837-9.
BACKGROUND
The occurrence of colorectal cancer has doubled over the last 50 years and many people are living with the disease in the palliative phase. Therefore, it is important that healthcare personnel have knowledge about the patient's health-related quality of life (HRQoL). The aim of this review is to investigate how HRQoL is reported by means of different measures for patients in the palliative phase of colorectal cancer and examine which sociodemographic and clinical factors are associated with the mean scores reported for HRQoL.
METHOD
A systematic review and meta-analysis using forest plots in STATA were conducted. The databases MEDLINE, CINAHL, Embase, Amed, and SveMed+ were used for the systematic searches with combinations of terms for colorectal cancer, the palliative phase and HRQoL. The Cochrane handbook and the PRISMA checklist from 2009 were utilised.
RESULTS
In total, 710 articles were identified. Eleven quantitative studies met the inclusion criteria and six were included in the meta-analysis. Five of the 11 studies had a longitudinal design, while the other six had a cross-sectional design. The meta-analyzes shows that the average HRQoL in palliative phase was 62.9 (56.8-69.0) 15D was 0.76 (0.73-0.79), EQ-5D was 0.67 (0.62-0.73), and VAS was 64.1 (53.7-74.4). Multiple sociodemographic and clinical variables were associated with HRQoL and a higher prevalence of common cancer symptoms were reported than gastrointestinal symptoms.
CONCLUSION
This systematic review revealed that patients with colorectal cancer report low HRQoL. Furthermore, it shows that what affects HRQoL is complicated, including multiple clinical and sociodemographic variables. This underlines the need for further research. To ensure the best possible care, it is important that all healthcare professionals have easy access to knowledge about HRQoL in patients with colorectal cancer, and what impacts it in the last phase of life.
背景
在过去的 50 年中，结直肠癌的发病率增加了一倍，许多人在姑息治疗阶段患有这种疾病。因此，医护人员了解患者的健康相关生活质量（HRQoL）非常重要。本研究旨在调查姑息治疗阶段的结直肠癌患者使用不同方法报告 HRQoL 的情况，并探讨哪些社会人口统计学和临床因素与报告的 HRQoL 平均得分相关。
方法
使用 STATA 中的森林图进行系统评价和荟萃分析。系统搜索使用了 MEDLINE、CINAHL、Embase、Amed 和 SveMed+ 数据库，使用了结直肠癌、姑息治疗阶段和 HRQoL 的术语组合。使用了 2009 年的 Cochrane 手册和 PRISMA 清单。
结果
共确定了 710 篇文章。11 项定量研究符合纳入标准，其中 6 项纳入荟萃分析。11 项研究中有 5 项为纵向设计，其余 6 项为横断面设计。荟萃分析显示，姑息治疗阶段的平均 HRQoL 为 62.9（56.8-69.0），15D 为 0.76（0.73-0.79），EQ-5D 为 0.67（0.62-0.73），VAS 为 64.1（53.7-74.4）。多项社会人口统计学和临床变量与 HRQoL 相关，报告的常见癌症症状比胃肠道症状更为普遍。
结论
本系统评价显示，结直肠癌患者报告的 HRQoL 较低。此外，它表明影响 HRQoL 的因素很复杂，包括多种临床和社会人口统计学变量。这强调了进一步研究的必要性。为了确保提供尽可能好的护理，所有医护人员都应该能够轻松获得有关结直肠癌患者 HRQoL 的知识，以及生命最后阶段影响 HRQoL 的因素。
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