Wang Zhilin, Huang Linzhu, Zhang Xinyu, Zhang Xinyue, Huang Liwei, Zhu Xiaoying, Long Xidai, Cao Demin, Li Yulei
Youjiang Medical University for Nationalities, Baise, China.
Jiangxi Provincial Key Laboratory of Conservation Biology, College of Forestry, Jiangxi Agricultural University, Nanchang, China.
PLoS Negl Trop Dis. 2025 Apr 2;19(4):e0012962. doi: 10.1371/journal.pntd.0012962. eCollection 2025 Apr.
The recent surge in incidence and geographic spread of OROV infections poses an escalating threat to global public health. However, studies exploring the clinical signs of OROV infection remains exceedingly limited.
We searched for OROV studies published until June 17, 2024, in several electronic databases including MEDLINE, EMBASE, SCOPUS, and the Cochrane Library.
In total, 15 studies involving 806 patients with OROV infection were eligible for inclusion. General symptoms with fever and headache were the most common. Gastrointestinal disturbances like nausea/vomiting, anorexia, and odynophagia were also prevalent, along with ocular symptoms, mainly retro-orbital pain, photophobia, and redness. Respiratory symptoms, such as cough, sore throat and nasal congestion, are present, and skin-related issues like rash, pruritus, and pallor were also identified.
Overall, this study provides a foundational understanding of OROV's clinical manifestations to guide diagnosis, management, and public health interventions against this neglected tropical disease.
最近奥罗波凯病毒（OROV）感染的发病率激增以及地域扩散对全球公共卫生构成了日益严重的威胁。然而，探索OROV感染临床症状的研究仍然极为有限。
我们在包括MEDLINE、EMBASE、SCOPUS和Cochrane图书馆在内的多个电子数据库中检索了截至2024年6月17日发表的OROV研究。
总共15项涉及806例OROV感染患者的研究符合纳入标准。最常见的一般症状是发热和头痛。恶心/呕吐、厌食和吞咽痛等胃肠道不适也很普遍，还有眼部症状，主要是眶后疼痛、畏光和眼红。存在咳嗽、喉咙痛和鼻塞等呼吸道症状，还发现了皮疹、瘙痒和苍白等与皮肤相关的问题。
总体而言，本研究为OROV的临床表现提供了基本认识，以指导针对这种被忽视的热带病的诊断、管理和公共卫生干预措施。
