Jain Aditya, Jangid Tanvi, Jangir Ram Niwas, Bhardwaj Gauri Shankar
Department of Zoology, University of Rajasthan, Jaipur, Rajasthan, 302004, India.
Protoplasma. 2025 Apr 3. doi: 10.1007/s00709-025-02057-x.
Diabetes mellitus is a chronic condition marked by high blood glucose levels, resulting from either insufficient insulin production or poor insulin function. While conventional treatments have progressed, there is growing interest in alternative therapies, especially polyherbal formulations, due to their natural origin, cost-effectiveness, and fewer side effects. This review uniquely explores the antidiabetic potential of polyherbal formulations derived from various plants, focusing on their synergistic effects, where combinations of plant species work together to enhance therapeutic, outcomes. It discusses common plants used, types of extracts, plant parts, and dosing regimens in experimental studies. Both in vitro and in vivo models are examined to assess the effectiveness of these formulations in managing diabetes. The mechanisms behind their antidiabetic action-such as boosting insulin secretion, improving insulin sensitivity, regulating glucose metabolism, and reducing oxidative stress and inflammation-are highlighted. Overall, polyherbal formulations offer significant promise for integrating into diabetes management and reducing complications when used alongside conventional therapies. This review underscores the novelty of using polyherbal combinations to enhance diabetes treatment, offering a holistic and cost-effective approach to management. In conclusion, further research into these formulations could lead to more accessible and personalized therapeutic options for diabetes patients worldwide.
糖尿病是一种以血糖水平升高为特征的慢性疾病，其病因要么是胰岛素分泌不足，要么是胰岛素功能不佳。虽然传统治疗方法已有进展，但由于其天然来源、成本效益和较少的副作用，人们对替代疗法，尤其是多草药配方的兴趣日益浓厚。本综述独特地探讨了源自各种植物的多草药配方的抗糖尿病潜力，重点关注它们的协同作用，即植物物种组合共同发挥作用以提高治疗效果。它讨论了实验研究中使用的常见植物、提取物类型、植物部位和给药方案。同时研究了体外和体内模型，以评估这些配方在控制糖尿病方面的有效性。强调了它们抗糖尿病作用背后的机制，如促进胰岛素分泌、提高胰岛素敏感性、调节葡萄糖代谢以及减少氧化应激和炎症。总体而言，多草药配方在与传统疗法联合使用时，对于融入糖尿病管理和减少并发症具有重大前景。本综述强调了使用多草药组合增强糖尿病治疗的新颖性，提供了一种全面且具有成本效益的管理方法。总之，对这些配方的进一步研究可能为全球糖尿病患者带来更易获得且个性化的治疗选择。
